AC T06243
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ID T06243
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DT 29.09.2004 (created); oke.
DT 19.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA HMGB1
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SY high-mobility group box 1; HMG1; HMG3; HMGB1; SBP-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G010037 HMGB1; HGNC: HMGB1.
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SF both HMGboxes A and B can interact with p73alpha [1];
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FF architectural DNA bending and looping protein;
FF stimulates p73alpha binding to DNA [1];
FF expression is enhanced in cisplatin-resistant cells (cisplatin is an anticancer drug) [3];
FF stimulates p53- and p73-dependent transcriptional activation [1];
FF enhances Sp1 binding to its site in the bax promoter [1];
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IN T22424 BAF57; human, Homo sapiens.
IN T04931 p73alpha; human, Homo sapiens.
IN T06137 p73beta; human, Homo sapiens.
IN T01003 SSRP1; human, Homo sapiens.
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BS R59000.
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DR TRANSPATH: MO000043844.
DR UniProtKB: P09429; HMG1_HUMAN.
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RN [1]; RE0024867.
RX PUBMED: 11748232.
RA Stros M., Ozaki T., Bacikova A., Kageyama H., Nakagawara A.
RT HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.
RL J. Biol. Chem. 277:7157-7164 (2002).
RN [2]; RE0024870.
RX PUBMED: 8661151.
RA Ferrari S., Finelli P., Rocchi M., Bianchi M. E.
RT The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.
RL Genomics 35:367-371 (1996).
RN [3]; RE0024886.
RX PUBMED: 11245470.
RA Nagatani G., Nomoto M., Takano H., Ise T., Kato K., Imamura T., Izumi H., Makishima K., Kohno K.
RT Transcriptional activation of the human HMG1 gene in cisplatin-resistant human cancer cells.
RL Cancer Res. 61:1592-1597 (2001).
RN [4]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
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