AC T08534
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ID T08534
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DT 07.02.2006 (created); jag.
DT 16.10.2008 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA c-Fos
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SY c-Fos; FBJ osteosarcoma oncogene; p55(c-fos).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000486 Fos.
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CL C0008; bZIP.
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SZ 380 AA; 40.8 kDa (cDNA) (calc.), 55-68 kDa (SDS) [3]
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SQ MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANF
SQ IPTVTAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTQSAGAYARAGMVKTVSGGRA
SQ QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
SQ TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEASTPESEEAFT
SQ LPLLNDPEPKPSLEPVKSISNVELKAEPFDDFLFPASSRPSGSETSRSVPDVDLSGSFYA
SQ ADWEPLHSNSLGMGPMVTELEPLCTPVVTCTPGCTTYTSSFVFTYPEADSFPSCAAAHRK
SQ GSSSNEPSSDSLSSPTLLAL
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SC Swiss-Prot#P01101
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FT 60 84 
N-terminal trans-activation domain (N-TA) [8].
FT 135 199 
PF00170; bZIP transcription factor.
FT 135 199 
SM00338; brlzneu.
FT 137 200 
PS50217; BZIP.
FT 210 270 
C-terminal transcription activation domain (C-TA) [4].
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IN T08444 ATF-4; mouse, Mus musculus.
IN T08587 c-Jun; mouse, Mus musculus.
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MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03815 V$CFOS_Q6.
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BS R25559.
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DR TRANSPATH: MO000060047.
DR EMBL: D12551;
DR EMBL: J00370;
DR EMBL: K03231;
DR EMBL: M23768;
DR EMBL: M65003;
DR EMBL: V00727;
DR UniProtKB: P01101;
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RN [1]; RE0000136.
RX PUBMED: 6319013.
RA Curran T., Miller A. D., Zokas L., Verma I. M.
RT Viral and cellular fos proteins: a comparative analysis
RL Cell 36:259-268 (1984).
RN [2]; RE0004659.
RX PUBMED: 1904542.
RA Abate C., Luk D., Curran T.
RT Transcriptional regulation by Fos and Jun in vitro: Interaction among multiple activator and regulator domains
RL Mol. Cell. Biol. 11:3624-3632 (1991).
RN [3]; RE0004798.
RX PUBMED: 6283132.
RA Curran T., Teich N. M.
RT Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-Dalton phosphoprotein
RL J. Virol. 42:114-122 (1982).
RN [4]; RE0004812.
RX PUBMED: 2108402.
RA Hirai S.-I., Bourachot D., Yaniv M.
RT Both Jun and Fos contribute to transcription activation by the heterodimer
RL Oncogene 5:39-46 (1990).
RN [5]; RE0004825.
RX PUBMED: 2122257.
RA Ofir R., Dwarki V. J., Rashid D., Verma I. M.
RT Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter
RL Nature 348:80-82 (1990).
RN [6]; RE0047989.
RX PUBMED: 15708845.
RA Tanos T., Marinissen M. J., Leskow F. C., Hochbaum D., Martinetto H., Gutkind J. S., Coso O. A.
RT Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.
RL J. Biol. Chem. 280:18842-18852 (2005).
RN [7]; RE0053117.
RX PUBMED: 15312241.
RA Kondo T., Kitazawa R., Maeda S., Kitazawa S.
RT 1 alpha,25 dihydroxyvitamin D3 rapidly regulates the mouse osteoprotegerin gene through dual pathways.
RL J. Bone Miner. Res. 19:1411-1419 (2004).
RN [8]; RE0004887.
RX PUBMED: 8137828.
RA Jooss K. U., Funk M., Mueller R.
RT An autonomous N-terminal transactivation domain in Fos protein plays a crucial role in transformation
RL EMBO J. 13:1467-1475 (1994).
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