AC T09048
XX
ID T09048
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DT 09.06.2006 (created); sla.
DT 24.07.2013 (updated); uat.
CO Copyright (C), QIAGEN.
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FA HNF-1alpha
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SY APF; Hepatocyte Nuclear Factor 1alpha; HNF-1A; HNF1; LF-B1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013737 Hnf1a.
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CL C0007; POU; 3.1.10.7.1.1.
XX
SZ 628 AA; 67.2 kDa (cDNA) (calc.), 92-98 kDa (SDS)
XX
SQ MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTEL
SQ PNGLGETRGSEDDTDDDGEDFAPPILKEPENLSPEEAAHQKAVVESLLQEDPWRVAKMVK
SQ SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA
SQ GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE
SQ CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALP
SQ AHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSS
SQ LLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPAS
SQ LGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ
SQ SHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQV
SQ FTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSD
SQ SNGHSHLLPSNHSVIETFISTQMASSSQ
XX
SC Swiss-Prot#P22361-1
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FT 1 176 
PF04814; Hepatocyte nuclear factor 1 (HNF-1), N termi.
FT 118 554 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 197 278 
PS50071; HOMEOBOX_2.
FT 199 282 
SM00389; HOX_1.
FT 208 219 
helix 1 [11].
FT 226 240 
helix 2 [11].
FT 261 274 
helix 3 [11].
FT 282 539 
PF04812; Hepatocyte nuclear factor 1 (HNF-1), beta is.
FT 540 628 
PF04813; Hepatocyte nuclear factor 1 (HNF-1), alpha i.
XX
IN T08574 C/EBPalpha; rat, Rattus norvegicus.
IN T09410 C/EBPbeta; Mammalia.
IN T23083 Cdx-1; Mammalia.
IN T09327 Cdx-2; human, Homo sapiens.
XX
MX M02013 V$HNF1A_Q5.
MX M00132 V$HNF1_01.
MX M01379 V$HNF1_02.
MX M00206 V$HNF1_C.
MX M00790 V$HNF1_Q6.
MX M01011 V$HNF1_Q6_01.
MX M02815 V$TCF1_06.
MX M02919 V$TCF1_07.
XX
BS R25948.
BS R25959.
BS R25946.
BS R03666.
BS R04254.
BS R40249.
BS R20696.
BS R57147.
BS R13053.
BS R02045.
BS R38656.
BS R38657.
BS R32185.
BS R32896.
BS R20965.
BS R18931.
BS R00439.
BS R34465.
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DR TRANSPATH: MO000082731.
DR EMBL: M57966;
DR UniProtKB: P22361-1;
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RN [1]; RE0000510.
RX PUBMED: 2065662.
RA Kuo C. J., Mendel D. B., Hansen L. P., Crabtree G. R.
RT Independent regulation of HNF-1alpha and HNF-1beta by retinoic acid in F9 teratocarcinoma cells
RL EMBO J. 10:2231-2236 (1991).
RN [2]; RE0000675.
RX PUBMED: 2044952.
RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R.
RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
RL Genes Dev. 5:1042-1056 (1991).
RN [3]; RE0001365.
RX PUBMED: 1694011.
RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann W., Hudson G., Fey G. H.
RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor III Gene Is Controlled by a Novel Combination of cis-Acting Regulatory Elements
RL Mol. Cell. Biol. 10:3483-3491 (1990).
RN [4]; RE0001386.
RX PUBMED: 2601716.
RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L., Ting L.-P.
RT A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the Large Surface Protein Gene of Human Hepatitis B Virus
RL Mol. Cell. Biol. 9:5189-5197 (1989).
RN [5]; RE0001392.
RX PUBMED: 2601701.
RA Tsutsumi K.-I., Ito K., Ishikawa K.
RT Developmental Appearance of Transcription Factors That Regulate Liver-Specific Expression of the Aldolase B Gene
RL Mol. Cell. Biol. 9:4923-4931 (1989).
RN [6]; RE0001582.
RX PUBMED: 1990282.
RA Liu J.-K., DiPersio C. M., Zaret K. S.
RT Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro
RL Mol. Cell. Biol. 11:773-784 (1991).
RN [7]; RE0002415.
RX PUBMED: 2263635.
RA Kuo C. J., Conley P. B., Hsieh C.-L., Francke U., Crabtree S.
RT Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
RL Proc. Natl. Acad. Sci. USA 87:9838-9842 (1990).
RN [8]; RE0002595.
RX PUBMED: 3499668.
RA Courtois G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R.
RT Interaction of a liver-specific nuclear factor with the fibrinogen and alpha1-antitrypsin promoters
RL Science 238:688-692 (1987).
RN [9]; RE0004692.
RX PUBMED: 1354855.
RA Bach I., Pontoglio M., Yaniv M.
RT Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1)
RL Nucleic Acids Res. 20:4199-4204 (1992).
RN [10]; RE0004693.
RX PUBMED: 1734282.
RA Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell J. E., Crabtree G. R.
RT A transcriptional hierarchy involved in mammalian cell-type specification
RL Nature 355:457-461 (1992).
RN [11]; RE0004697.
RX PUBMED: 8491172.
RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K.
RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain
RL EMBO J. 12:1797-1803 (1993).
RN [12]; RE0048826.
RX PUBMED: 16321657.
RA Staloch L. J., Divine J. K., Witten J. T., Simon T. C.
RT C/EBP and Cdx family factors regulate liver fatty acid binding protein transgene expression in the small intestinal epithelium.
RL Biochim. Biophys. Acta 1731:168-178 (2005).
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