AC T09196
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ID T09196
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DT 08.08.2006 (created); sri.
DT 17.07.2009 (updated); pro.
CO Copyright (C), QIAGEN.
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FA HSF2A
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SY heat shock (transcription) factor 2; HSF-2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003945 HSF2; HGNC: HSF2.
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CL C0050; HSF.
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SZ 536 AA; 60.3 kDa (cDNA) (calc.), 87 kDa (SDS) [1]
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SQ MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS
SQ FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK
SQ IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ
SQ FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE
SQ RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ
SQ SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL
SQ LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK
SQ NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP
SQ IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS
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SC Swiss-Prot#Q03933-1
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FT 6 110 
SM00415; HSF.
FT 8 200 
PF00447; HSF-type DNA-binding.
FT 10 77 
PS50140; HSF_ETS.
FT 229 513 
PF06546; Vertebrate heat shock transcription fact.
FT 440 451 
region of homology with HSF2 [3].
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IN T01042 HSF1-L; human, Homo sapiens.
IN T09092 PC4; human, Homo sapiens.
IN T08496 TFIIB; human, Homo sapiens.
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MX M00147 V$HSF2_01.
MX M01244 V$HSF2_02.
MX M07358 V$HSF2_Q6.
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BS R00762.
BS R15803.
BS R15806.
BS R15816.
BS R15817.
BS R15818.
BS R15819.
BS R15820.
BS R15797.
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DR TRANSPATH: MO000084504.
DR EMBL: M65217; HSHSF2.
DR UniProtKB: Q03933-1;
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RN [1]; RE0002539.
RX PUBMED: 1871106.
RA Schuetz T. J., Gallo G. J., Sheldon L., Temps P., Kingston R. E.
RT Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans
RL Proc. Natl. Acad. Sci. USA 88:6911-6915 (1991).
RN [2]; RE0003104.
RX PUBMED: 1508207.
RA Sistonen L., Sarge K. D., Phillips B., Abravaya K., Morimoto R. I.
RT Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells
RL Mol. Cell. Biol. 12:4104-4111 (1992).
RN [3]; RE0005280.
RX PUBMED: 8421783.
RA Rabindran S. K., Haroun R. I., Clos J., Wisniewski J., Wu C.
RT Regulation of heat shock factor trimer formation: role of a conserved leucine zipper
RL Science 259:230-234 (1993).
RN [4]; RE0025006.
RX PUBMED: 12813038.
RA He H., Soncin F., Grammatikakis N., Li Y., Siganou A., Gong J., Brown S. A., Kingston R. E., Calderwood S. K.
RT Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress.
RL J. Biol. Chem. 278:35465-35475 (2003).
RN [5]; RE0025044.
RX PUBMED: 10224043.
RA Hong Y., Sarge K. D.
RT Regulation of protein phosphatase 2A activity by heat shock transcription factor 2.
RL J. Biol. Chem. 274:12967-12970 (1999).
RN [6]; RE0025045.
RX PUBMED: 10336892.
RA Pirkkala L., Alastalo T. P., Nykanen P., Seppa L., Sistonen L.
RT Differentiation lineage-specific expression of human heat shock transcription factor 2.
RL FASEB J. 13:1089-1098 (1999).
RN [7]; RE0031850.
RX PUBMED: 11005381.
RA Yuan C. X., Gurley W. B.
RT Potential targets for HSF1 within the preinitiation complex.
RL Cell Stress Chaperones 5:229-42 (2000).
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