AC T09278
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ID T09278
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DT 30.08.2006 (created); jag.
DT 03.01.2012 (updated); sla.
CO Copyright (C), QIAGEN.
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FA IRF-4-isoform1
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SY interferon regulatory factor 4; IRF-4; IRF4; lsirf; LSIRF-2; Lymphocyte Specific Interferon Regulatory Factor; lymphoid-specific interferon regulatory factor; NF-EM5; Nuclear factor EM5; Pip; PU.1 interaction partner; transcriptional activator pip.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005704 Irf4.
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CL C0022; trp; 3.5.3.0.4.1.
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SZ 450 AA; 51.6 kDa (cDNA) (calc.), 46 kDa (SDS)
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SQ MNLETGSRGSEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQ
SQ DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD
SQ PYKVYRIVPEGAKKGAKQLTLDDTQMAMGHPYPMTAPYGSLPAQQVHNYMMPPHDRSWRD
SQ YAPDQSHPEIPYQCPVTFGPRGHHWQGPSCENGCQVTGTFYACAPPESQAPGIPIEPSIR
SQ SAEALALSDCRLHICLYYRDILVKELTTTSPEGCRISHGHTYDVSNLDQVLFPYPDDNGQ
SQ RKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFD
SQ TQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN
SQ TGHFLRGYELPEHVTTPDYHRSLRHSSIQE
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SC translated from EMBL #U34307
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FT 1 134 
DNA-binding domain [6].
FT 17 130 
SM00348; IRF.
FT 20 24 
transcriptional synergy with E47 [8].
FT 23 130 
PF00605; Interferon regulatory factor transcription f.
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IN T10873 c-Ets-1; Mammalia.
IN T15312 c-Ets-2; Mammalia.
IN T10472 Fli-1; Mammalia.
IN T10429 PU.1; mouse, Mus musculus.
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MX M02768 V$IRF4_03.
MX M02872 V$IRF4_04.
MX M07323 V$IRF4_Q5.
MX M08886 V$IRF4_Q5_01.
MX M01883 V$IRF4_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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DR TRANSPATH: MO000085966.
DR EMBL: U11692; MM11692.
DR EMBL: U20949; MM20949.
DR EMBL: U34307;
DR UniProtKB: Q64287-1;
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RN [1]; RE0002720.
RX PUBMED: 8456286.
RA Pongubala J. M. R., van Beveren C., Nagulapalli S., Klemsz M. J., McKercher S. R., Maki R. A., Atchison M. L.
RT Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation
RL Science 259:1622-1625 (1993).
RN [2]; RE0003064.
RX PUBMED: 1729611.
RA Pongubala J. M. R., Nagulapalli S., Klemsz M. J., McKercher S. R., Maki R. A., Atchison M. L.
RT PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity
RL Mol. Cell. Biol. 12:368-378 (1992).
RN [3]; RE0003458.
RX PUBMED: 8413244.
RA Eisenbeis C. F., Singh H., Storb U.
RT Pu-1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda2-4 enhancer
RL Mol. Cell. Biol. 13:6452-6461 (1993).
RN [4]; RE0003460.
RX PUBMED: 7541907.
RA Matsuyama T., Grossman A., Mittruecker H.-W., Siderovski D. P., Kiefer F., Kawakami T., Richardson C. D., Taniguchi T., Yoshinaga S. K., Mak T. W.
RT Molecular cloning of LSIRF, lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
RL Nucleic Acids Res. 23:2127-2136 (1995).
RN [5]; RE0006335.
RX PUBMED: 8999800.
RA Mittruecker H. W., Matsuyama T., Grossman A., Kuendig T. M., Potter J., Shahinian A., Wakeham A., Patterson B., Ohashi P. S., Mak T. W.
RT Requirement for the transcription factor LSIRF/IRF4 for mature B and T Lymphocyte function
RL Science 275:540-543 (1997).
RN [6]; RE0016554.
RX PUBMED: 7797077.
RA Eisenbeis C. F., Singh H., Storb U.
RT Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
RL Genes Dev. 9:1377-1387 (1995).
RN [7]; RE0016555.
RX PUBMED: 9551977.
RA Perkel J. M., Atchison M. L.
RT A two-step mechanism for recruitment of Pip by PU.1
RL J. Immunol. 160:241-252 (1998).
RN [8]; RE0023124.
RX PUBMED: 12242308.
RA Nagulapalli S., Goheer A., Pitt L., McIntosh L. P., Atchison M. L.
RT Mechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts.
RL Mol. Cell. Biol. 22:7337-7350 (2002).
RN [9]; RE0023159.
RX PUBMED: 12372320.
RA Escalante C. R., Shen L., Escalante M. C., Brass A. L., Edwards T. A., Singh H., Aggarwal A. K.
RT Crystallization and characterization of PU.1/IRF-4/DNA ternary complex.
RL J. Struct. Biol. 139:55-59 (2002).
RN [10]; RE0024415.
RX PUBMED: 11425859.
RA Matsumoto M., Hisatake K., Nogi Y., Tsujimoto M.
RT Regulation of receptor activator of NF-kappaB ligand-induced tartrate-resistant acid phosphatase gene expression by PU.1-interacting protein/interferon regulatory factor-4. Synergism with microphthalmia transcription factor.
RL J. Biol. Chem. 276:33086-33092 (2001).
RN [11]; RE0048446.
RX PUBMED: 16236719.
RA Negishi H., Ohba Y., Yanai H., Takaoka A., Honma K., Yui K., Matsuyama T., Taniguchi T., Honda K.
RT Negative regulation of Toll-like-receptor signaling by IRF-4.
RL Proc. Natl. Acad. Sci. USA 102:15989-15994 (2005).
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