AC T09944
XX
ID T09944
XX
DT 23.11.2006 (created); din.
DT 05.12.2007 (updated); bch.
CO Copyright (C), QIAGEN.
XX
FA DAX1
XX
SY AHCH; DAX-1; NR0B1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002819 NR0B1; HGNC: NR0B1.
XX
CL C0002; CC (rec); 2.1.7.0.1.1.
XX
SZ 470 AA; 51.7 kDa (cDNA) (calc.).
XX
SQ MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNV
SQ ALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGL
SQ PGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQR
SQ PGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSS
SQ GALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELA
SQ QDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQA
SQ IKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQ
SQ GPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI
XX
SC Swiss-Prot#P51843-1
XX
FT 1 204 
contains region mainly responsible for RNA-binding [8].
FT 256 440 
SM00430; holi.
FT 259 465 
PF00104; Ligand-binding domain of nuclear hormon.
XX
IN T02752 LXR-alpha; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T00696 PR B; human, Homo sapiens.
XX
MX M01248 V$DAX1_01.
XX
DR TRANSPATH: MO000093029.
DR EMBL: S74720;
DR UniProtKB: P51843-1;
XX
RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013664.
RX PUBMED: 7990953.
RA Zanaria E., Muscatelli F., Bardoni B., Strom T. M., Guioli S., Guo W., Lalli E., Moser C., Walker A. P., McCabe E. R., et al.
RT An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
RL Nature 372:635-641 (1994).
RN [3]; RE0013665.
RX PUBMED: 7990958.
RA Muscatelli F., Strom T. M., Walker A. P., Zanaria E., Recan D., Meindl A., Bardoni B., Guioli S., Zehetner G., Rabl W., et al.
RT Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
RL Nature 372:672-676 (1994).
RN [4]; RE0013666.
RX PUBMED: 9003500.
RA Schwartz M., Blichfeldt S., Muller J.
RT X-linked adrenal hypoplasia in a large Greenlandic family. Detection of a missense mutation (N4401) in the DAX-1 gene; implication for genetic counselling and carrier diagnosis
RL Hum. Genet. 99:83-87 (1997).
RN [5]; RE0016767.
RX PUBMED: 8754790.
RA Majdic G., Saunders P. T.
RT Differential patterns of expression of DAX-1 and steroidogenic factor-1 (SF-1) in the fetal rat testis
RL Endocrinology 137:3586-3589 (1996).
RN [6]; RE0016769.
RX PUBMED: 9566914.
RA Crawford P. A., Dorn C., Sadovsky Y., Milbrandt J.
RT Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
RL Mol. Cell. Biol. 18:2949-2956 (1998).
RN [7]; RE0016772.
RX PUBMED: 11301600.
RA Goodfellow P. N., Camerino G.
RT DAX-1, an "antitestis" gene
RL EXS 91:57-69 (2001).
RN [8]; RE0016774.
RX PUBMED: 10848616.
RA Lalli E., Ohe K., Hindelang C., Sassone-Corsi P.
RT Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA
RL Mol. Cell. Biol. 20:4910-4921 (2000).
RN [9]; RE0030408.
RX PUBMED: 12771131.
RA Agoulnik I. U., Krause W. C., Bingman W. E. 3rd, Rahman H. T., Amrikachi M., Ayala G. E., Weigel N. L.
RT Repressors of androgen and progesterone receptor action.
RL J. Biol. Chem. 278:31136-48 (2003).
RN [10]; RE0051310.
RX PUBMED: 16354658.
RA Albers M., Blume B., Schlueter T., Wright M. B., Kober I., Kremoser C., Deuschle U., Koegl M.
RT A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
RL J. Biol. Chem. 281:4920-4930 (2006).
XX
//