AC T32366
XX
ID T32366
XX
DT 16.01.2006 (created); jma.
DT 09.04.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA SIRT1-isoform1
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SY silent information regulator type 1; SIR2alpha; sirtuin type 1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006716 Sirt1.
XX
SZ 737 AA; 80.4 kDa (cDNA) (calc.).
XX
SQ MADEVALALQAAGSPSAAAAMEAASQPADEPLRKRPRRDGPGLGRSPGEPSAAVAPAAAG
SQ CEAASAAAPAALWREAAGAAASAEREAPATAVAGDGDNGSGLRREPRAADDFDDDEGEEE
SQ DEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSSDWTPRPRIGPYTFV
SQ QQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVK
SQ LLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRP
SQ FFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFAT
SQ ASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKY
SQ DKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINE
SQ LCHRLGGEYAKLCCNPVKLSEITEKPPRPQKELVHLSELPPTPLHISEDSSSPERTVPQD
SQ SSVIATLVDQATNNNVNDLEVSESSCVEEKPQEVQTSRNVENINVENPDFKAVGSSTADK
SQ NERTSVAETVRKCWPNRLAKEQISKRLEGNQYLFVPPNRYIFHGAEVYSDSEDDVLSSSS
SQ CGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDTERPECAGGSGFGADGGDQEVVNEA
SQ IATRQELTDVNYPSDKS
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SC translated from EMBL:AF214646
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FT 236 490 
PS50305; SIRTUIN.
FT 253 439 
PF02146; SIR2.
XX
IN T10259 Clock-L; mouse, Mus musculus.
IN T09104 FOXO1A; mouse, Mus musculus.
IN T25678 GCN5-L; human, Homo sapiens.
IN T08435 GCN5-S; human, Homo sapiens.
IN T06148 p/CAF; human, Homo sapiens.
XX
DR TRANSPATH: MO000056936.
DR EMBL: AF214646;
DR UniProtKB: Q923E4;
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RN [1]; RE0033289.
RX PUBMED: 15220471.
RA Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A.
RT Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 101:10042-7 (2004).
RN [2]; RE0048066.
RX PUBMED: 12887892.
RA Fulco M., Schiltz R. L., Iezzi S., King M. T., Zhao P., Kashiwaya Y., Hoffman E., Veech R. L., Sartorelli V.
RT Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.
RL Mol. Cell 12:51-62 (2003).
RN [3]; RE0048104.
RX PUBMED: 15632193.
RA Bouras T., Fu M., Sauve A. A., Wang F., Quong A. A., Perkins N. D., Hay R. T., Gu W., Pestell R. G.
RT SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
RL J. Biol. Chem. 280:10264-10276 (2005).
RN [4]; RE0049242.
RX PUBMED: 16923962.
RA Fu M., Liu M., Sauve A. A., Jiao X., Zhang X., Wu X., Powell M. J., Yang T., Gu W., Avantaggiati M. L., Pattabiraman N., Pestell T. G., Wang F., Quong A. A., Wang C., Pestell R. G.
RT Hormonal control of androgen receptor function through SIRT1.
RL Mol. Cell. Biol. 26:8122-8135 (2006).
RN [5]; RE0067815.
RX PUBMED: 18482975.
RA Hou X., Xu S., Maitland-Toolan K. A., Sato K., Jiang B., Ido Y., Lan F., Walsh K., Wierzbicki M., Verbeuren T. J., Cohen R. A., Zang M.
RT SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.
RL J. Biol. Chem. 283:20015-20026 (2008).
RN [6]; RE0068047.
RX PUBMED: 18687677.
RA Lan F., Cacicedo J. M., Ruderman N., Ido Y.
RT SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
RL J. Biol. Chem. 283:27628-27635 (2008).
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