AC T00177
XX
ID T00177
XX
DT 15.10.1992 (created); ewi.
DT 08.08.2012 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA CTF-2
XX
SY CAAT-binding transcription factor 2; CTF-2; CTF2; NF-1C2 (chick); NF1C2; NFI-C2; NFI/CTF-2; NFIC2 isoform 2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003997 NFIC; HGNC: NFIC.
XX
CL C0060; NF1; 7.1.2.0.3.2.
XX
SZ 430 AA; 47.9 kDa (cDNA) (calc.).
XX
SQ MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVK
SQ QKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWR
SQ LDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
SQ EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSL
SQ GELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSS
SQ SRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP
SQ SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPT
SQ RPLQTVPLWD
XX
SC Swiss-Prot#P08651-3
XX
FT 1 84 
interaction with p73alpha [4].
FT 1 186 
PS51080; CTF_NFI_2.
FT 16 359 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 57 164 
PF03165; MH1 domain.
FT 59 167 
SM00523; dwAneu5.
FT 208 430 
PF00859; CTF/NF-I family transcription modulation reg.
FT 239 285 
interaction with p53 [4].
XX
SF 6 splice variants are known: NF-1 T00539, CTF-1 T00176, CTF-2 (this entry), CTF-3 T00178, CTF-5 T02300, CTF-7 T02301 [2] [3];
XX
FF no recognizable transcription activation by CTF-2 [3];
FF activates transcription of HMG1 gene [4] [5];
FF expression on both mRNA and protein level is significantly enhanced in cisplatin-resistant KB-CP20 cells (cisplatin is an anticancer drug) [5];
FF binding to DNA can be stimulated by direct interactions with p73alpha T04931, but not with p53 [4];
XX
IN T00671 p53; human, Homo sapiens.
IN T04931 p73alpha; human, Homo sapiens.
XX
MX M01196 V$CTF1_01.
MX M00056 V$MYOGNF1_01.
MX M07300 V$NF1C_Q6.
MX M07363 V$NF1FAMILY_Q4.
MX M00193 V$NF1_Q6.
MX M00806 V$NF1_Q6_01.
MX M07364 V$NF1_Q6_02.
XX
BS R20671.
BS R20672.
BS R00506.
BS R15678.
BS R15679.
BS R01311.
BS R02209.
XX
DR TRANSPATH: MO000024752.
DR EMBL: X12492;
DR UniProtKB: P08651-3;
XX
RN [1]; RE0001784.
RX PUBMED: 3398920.
RA Santoro C., Mermod N., Andrews P. C., Tjian R.
RT A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs
RL Nature 334:218-224 (1988).
RN [2]; RE0003054.
RX PUBMED: 8171010.
RA Altmann H., Wendler W., Winnacker E. L.
RT Transcriptional activation by CTF proteins is mediated by a bipartite low-proline domain
RL Proc. Natl. Acad. Sci. USA 91:3901-3905 (1994).
RN [3]; RE0006390.
RX PUBMED: 8710515.
RA Wenzelides S., Altmann H., Wendler W., Winnacker E.-L.
RT CTF5- a new transcriptional activator of the NFI/CTF family
RL Nucleic Acids Res. 24:2416-2421 (1996).
RN [4]; RE0024885.
RX PUBMED: 12534345.
RA Uramoto H., Izumi H., Nagatani G., Ohmori H., Nagasue N., Ise T., Yoshida T., Yasumoto K., Kohno K.
RT Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression.
RL Biochem. J. 371:301-310 (2003).
RN [5]; RE0024886.
RX PUBMED: 11245470.
RA Nagatani G., Nomoto M., Takano H., Ise T., Kato K., Imamura T., Izumi H., Makishima K., Kohno K.
RT Transcriptional activation of the human HMG1 gene in cisplatin-resistant human cancer cells.
RL Cancer Res. 61:1592-1597 (2001).
XX
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