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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T00539 XX ID T00539 XX DT 15.10.1992 (created); ewi. DT 01.03.2016 (updated); sla. CO Copyright (C), QIAGEN. XX FA NF-1C-isoform1 XX SY CTF; CTF-1; CTF/NF-1; NF-1; NF-I; NF1C-isoform1; NFI; NFIC isoform 1; NFIC1; nuclear factor 1; TGGCA-binding protein. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003997 NFIC; HGNC: NFIC. XX CL C0060; NF1; 7.1.2.0.3.1. XX SZ 499 AA; 54.7 kDa (cDNA) (calc.). XX SQ MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVK SQ QKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWR SQ LDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA SQ EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSL SQ GELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSS SQ SRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHP SQ SSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQ SQ LKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFV SQ GLGPRDPAGIYQAQSWYLG XX SC Swiss-Prot#P08651-2 XX FT 1 186 PS51080; CTF_NFI_2. FT 16 359 PF00478; IMP dehydrogenase / GMP reductase domain. FT 57 164 PF03165; MH1 domain. FT 59 167 SM00523; dwAneu5. FT 208 499 PF00859; CTF/NF-I family transcription modulation reg. XX SF 6 splice variants are known: NF-1C-isoform1 (this entry), CTF-1 T00176, CTF-2 T00177, CTF-3 T00178, CTF-5 T02300, CTF-7 T02301 [28] [29]; SF O-glycosylation; XX MX M01196 V$CTF1_01. MX M00056 V$MYOGNF1_01. MX M07300 V$NF1C_Q6. MX M07363 V$NF1FAMILY_Q4. MX M00193 V$NF1_Q6. MX M00806 V$NF1_Q6_01. MX M07364 V$NF1_Q6_02. XX BS R00347. BS R00312. BS R01175. BS R01988. BS R00167. BS R00169. BS R01774. BS R00633. BS R00636. BS R00640. BS R01367. BS R00789. BS R00790. BS R00791. BS R00792. BS R00799. BS R00802. BS R00803. BS R00809. BS R00729. BS R00730. BS R00731. BS R00732. BS R00733. BS R00734. BS R00735. BS R00738. BS R00739. BS R00740. BS R00741. BS R00744. BS R00745. BS R00746. BS R00724. BS R00725. BS R00726. BS R00727. BS R00728. BS R31699. BS R20865. BS R03664. BS R00435. BS R00457. BS R04124. BS R04125. BS R04126. BS R00607. BS R00594. BS R01311. BS R11726. BS R11730. BS R26282. BS R02705. BS R00951. BS R00952. BS R00953. BS R01126. BS R00088. BS R03106. BS R04695. BS R02209. BS R01624. BS R03993. BS R03994. BS R03995. BS R18865. BS R01357. BS R01588. BS R01589. BS R04482. BS R04483. BS R04484. XX DR TRANSPATH: MO000009772. DR TRANSCOMPEL: C00310. DR TRANSCOMPEL: C00443. DR EMBL: X12492; DR UniProtKB: P08651-2; XX RN [1]; RE0000049. RX PUBMED: 2830985. RA Rossi P., Karsenty G., Roberts A. B., Roche N. S., Sporn M. B., de Crombrugghe B. RT A Nuclear Factor I Binding Site Mediates the Transcriptional Activation of a Type I Collagen Promoter by Transforming Growth Factor-beta RL Cell 52:405-414 (1988). RN [2]; RE0000315. RX PUBMED: 2767055. RA Cleat P. H., Hay R. T. RT Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication RL EMBO J. 8:1841-1848 (1989). RN [3]; RE0000364. RX PUBMED: 3015602. RA Hennighausen L., Fleckenstein B. RT Nuclear factor 1 interacts with five DNA elements in the promoter region of the human cytomegalovirus major immediate early gene RL EMBO J. 5:1367-1371 (1986). RN [4]; RE0000403. RX PUBMED: 3463507. RA Shaul Y., Ben-Levy R., De-Medina T. RT High affinity binding site for nuclear factor I next to the hepatitis B virus S gene promotor RL EMBO J. 5:1967-1971 (1986). RN [5]; RE0000459. RX PUBMED: 2303041. RA Gounari F., de Francesco R., Schmitt J., van der Vliet P., Cortese R., Stunnenberg H. RT Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication RL EMBO J. 9:559-566 (1990). RN [6]; RE0000653. RX PUBMED: 2542124. RA Toohey M. G., Jones K. A. RT In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions RL Genes Dev. 3:265-282 (1989). RN [7]; RE0000812. RX PUBMED: 2540170. RA Amemiya K., Traub R., Durham L., Major E. O. RT Interaction of a Nuclear Factor-1-like Protein with the Regulatory Region of Human Polyomavirus JC Virus RL J. Biol. Chem. 264:7025-7032 (1989). RN [8]; RE0000835. RX PUBMED: 3005289. RA Adhya S., Shneidman P. S., Hurwitz J. RT Reconstruction of adenovirus replication origins with a human nuclear factor I binding site RL J. Biol. Chem. 261:3339-3346 (1986). RN [9]; RE0000874. RX PUBMED: 3003068. RA Rosenfeld P. J., Kelly T. J. RT Purification of Nuclear Factor I by DNA Recognition Site Affinity Chromatography RL J. Biol. Chem. 261:1398-1408 (1986). RN [10]; RE0001129. RX PUBMED: 2926813. RA Janson L., Weller P., Pettersson U. RT Nuclear Factor I can Functionally Replace Transcription Factor Sp1 in a U2 Small Nuclear RNA Gene Enhancer RL J. Mol. Biol. 205:387-396 (1989). RN [11]; RE0001160. RX PUBMED: 2214023. RA Mul Y. M., Verrijzer C. P., van der Vliet P. C. RT Transcription factors NFI and NFIII/oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication RL J. Virol. 64:5510-5518 (1990). RN [12]; RE0001209. RX PUBMED: 3785168. RA Diffley J. F. X., Stillman B. RT Purification of a cellular, double-stranded DNA-binding protein required for initiation of adenovirus DNA replication by using a rapid filter-binding assay RL Mol. Cell. Biol. 6:1363-1373 (1986). RN [13]; RE0001247. RX PUBMED: 2542772. RA Dean D. C., Blakeley M. S., Newby R. F., Ghazal P., Hennighausen L., Bourgeois S. RT Forskolin Inducibility and Tissue-Specific Expression of the Fibronectin Promoter RL Mol. Cell. Biol. 9:1498-1506 (1989). RN [14]; RE0001274. RX PUBMED: 2725524. RA Ben-Levy R., Faktor O., Berger I., Shaul Y. RT Cellular Factors That Interact with the Hepatitis B Virus Enhancer RL Mol. Cell. Biol. 9:1804-1809 (1989). RN [15]; RE0001374. RX PUBMED: 2796988. RA Gustafson T. A., Kedes L. RT Identification of Multiple Proteins That Interact with Functional Regions of the Human Cardiac alpha-Actin Promoter RL Mol. Cell. Biol. 9:3269-3283 (1989). RN [16]; RE0001385. RX PUBMED: 2550803. RA Chakraborty T., Das G. C. RT Identification of HeLa Cell Nuclear Factors That Bind to and Activate the Early Promoter of Human Polyomavirus BK In Vitro RL Mol. Cell. Biol. 9:3821-3828 (1989). RN [17]; RE0001489. RX PUBMED: 2304457. RA Goyal N., Knox J., Gronostajski R. M. RT Analysis of multiple forms of nuclear factor I in human and murine cell lines RL Mol. Cell. Biol. 10:1041-1048 (1990). RN [18]; RE0001631. RX PUBMED: 1710025. RA Pecorino L. T., Darrow A. L., Strickland S. RT In vitro analysis of the tissue plasminogen activator promoter reveals a GC box-binding activity present in murine brain but undetectable in kidney and liver RL Mol. Cell. Biol. 11:3139-3147 (1991). RN [19]; RE0001814. RX PUBMED: 2833704. RA Mermod N., Williams T. J., Tjian R. RT Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro RL Nature 332:557-561 (1988). RN [20]; RE0001971. RX PUBMED: 2959908. RA Garcia J., Wu F., Gaynor R. RT Upstream regulatory regions required to stabilize binding to the TATA sequence in an adenovirus early promoter RL Nucleic Acids Res. 15:8367-8385 (1987). RN [21]; RE0001981. RX PUBMED: 2734104. RA Catala F., deBoer E., Habets G., Grosveld F. RT Nuclear protein factors and erythroid transcription of the human Agamma-globin gene RL Nucleic Acids Res. 17:3811-3827 (1989). RN [22]; RE0001985. RX PUBMED: 2308836. RA Courtois S. J., Lafontaine D. A., Lemaigre F. P., Durviaux S. M., Rousseau G. G. RT Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences and trans-activate the human growth hormone gene RL Nucleic Acids Res. 18:57-64 (1990). RN [23]; RE0001991. RX PUBMED: 2542901. RA Gloss B., Yeo-Gloss M., Meisterernst M., Rogge L., Winnacker E. L., Bernard H.-U. RT Clusters of nuclear factor I binding sites identify enhancers of several papillomaviruses but lone are not sufficient for enhancer function RL Nucleic Acids Res. 17:3519-3533 (1989). RN [24]; RE0002057. RX PUBMED: 2555785. RA Shelbourn S. L., Kothari S. K., Sissons J. G. P., Sinclair J. H. RT Repression of human cytomegalovirus gene expression associated with a novel immediate early regulatory region binding factor RL Nucleic Acids Res. 17:9165-9171 (1989). RN [25]; RE0002283. RX PUBMED: 6588377. RA Gronostajski R. M., Nagata K., Hurwitz J. RT Isolation of human DNA sequences that bind to nuclear factor I, a host protein involved in adenovirus DNA replication RL Proc. Natl. Acad. Sci. USA 81:4013-4017 (1984). RN [26]; RE0002309. RX PUBMED: 3035545. RA Ghazal P., Lubon H., Fleckenstein B., Hennighausen L. RT Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer RL Proc. Natl. Acad. Sci. USA 84:3658-3662 (1987). RN [27]; RE0002479. RX PUBMED: 1902571. RA Trujillo M. A., Letovsky J., Maguire H. F., Lopez-Cabrera M., Siddiqui A. RT Functional analysis of a liver-specific enhancer of the hepatitis B virus RL Proc. Natl. Acad. Sci. USA 88:3797-3801 (1991). RN [28]; RE0003054. RX PUBMED: 8171010. RA Altmann H., Wendler W., Winnacker E. L. RT Transcriptional activation by CTF proteins is mediated by a bipartite low-proline domain RL Proc. Natl. Acad. Sci. USA 91:3901-3905 (1994). RN [29]; RE0006390. RX PUBMED: 8710515. RA Wenzelides S., Altmann H., Wendler W., Winnacker E.-L. RT CTF5- a new transcriptional activator of the NFI/CTF family RL Nucleic Acids Res. 24:2416-2421 (1996). XX //