TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00479 XX ID T00479 XX DT 26.01.1993 (created); hse. DT 25.08.2014 (updated); spk. CO Copyright (C), QIAGEN. XX FA Ikaros XX SY 5832432G11Rik; hlk-1; Ikaros; LyF-1; lymphoid transcription factor; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005193 Ikzf1. XX CL C0001; CH; XX SF at least five alternative splice variants are known, Ik-1 T01469, Ik-2 T01470, Ik-3 T01471, Ik-4 T01472, Ik-5 T01473 [2]; XX CP B cells, T cells. XX FF essential regulator for lymphoid lineage specification and subsequent proliferation in the T lineage [3]; FF lack of Ikarus (Ikaros) activity at the late stages of thymocyte maturation leads to uncontrolled lymphoproliferation and to the rapid development of malignant T cell leukemia and lymphoma [3]; XX IN T22468 BCL11A-isoform1; human, Homo sapiens. IN T09170 CtBP1-isoform1; human, Homo sapiens. IN T10217 GATA-1; Mammalia. IN T17995 GATA-2; Mammalia. XX MX M00086 V$IK1_01. MX M00087 V$IK2_01. MX M00088 V$IK3_01. MX M01169 V$IK_Q5. MX M07260 V$IK_Q5_01. MX M00141 V$LYF1_01. XX BS R15115. BS R15116. BS R14964. BS R15117. BS R26165. BS R07200. BS R07201. BS R07202. BS R07203. BS R07204. BS R07205. BS R07206. BS R07207. BS R07208. BS R07209. BS R07210. BS R15119. BS R00874. BS R03518. BS R03519. BS R14947. BS R14948. BS R21405. BS R02196. BS R04718. BS R14958. BS R25787. BS R15128. BS R59849. BS R02685. BS R02982. BS R14938. BS R14941. BS R03509. BS R03510. BS R03512. BS R03513. BS R24652. BS R24653. BS R24655. BS R24656. BS R24648. BS R24649. BS R24650. BS R24651. BS R25978. BS R21400. BS R03503. BS R03504. BS R14933. BS R14937. BS R15118. BS R14942. BS R14943. XX DR TRANSPATH: MO000024958. DR EMBL: L03547; MMIKAROS. DR UniProtKB: Q03267; IKAR_MOUSE. XX RN [1]; RE0001480. RX PUBMED: 1922043. RA Lo K., Landau N. R., Smale S. T. RT LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocytes-specific genes RL Mol. Cell. Biol. 11:5229-5243 (1991). RN [2]; RE0006501. RX PUBMED: 7935426. RA Hahm K., Ernst P., Lo K., Kim G. S., Turck C., Smale S. T. RT The lymphoid transcrption factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene RL Mol. Cell. Biol. 14:7111-7123 (1994). RN [3]; RE0006503. RX PUBMED: 7585946. RA Winandy S., Wu P., Georgopoulos K. RT A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma RL Cell 83:289-299 (1995). RN [4]; RE0024292. RX PUBMED: 1439790. RA Georgopoulos K., Moore D. D., Derfler B. RT Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. RL Science 258:808-812 (1992). RN [5]; RE0026561. RX PUBMED: 10766745. RA Koipally J., Georgopoulos K. RT Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity RL J. Biol. Chem. 275:19594-602 (2000). XX //