AC T00479
XX
ID T00479
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DT 26.01.1993 (created); hse.
DT 25.08.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Ikaros
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SY 5832432G11Rik; hlk-1; Ikaros; LyF-1; lymphoid transcription factor; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005193 Ikzf1.
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CL C0001; CH; 2.3.4.4.1.
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SF at least five alternative splice variants are known, Ik-1 T01469, Ik-2 T01470, Ik-3 T01471, Ik-4 T01472, Ik-5 T01473 [2];
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CP B cells, T cells.
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FF essential regulator for lymphoid lineage specification and subsequent proliferation in the T lineage [3];
FF lack of Ikarus (Ikaros) activity at the late stages of thymocyte maturation leads to uncontrolled lymphoproliferation and to the rapid development of malignant T cell leukemia and lymphoma [3];
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IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T09170 CtBP1-isoform1; human, Homo sapiens.
IN T10217 GATA-1; Mammalia.
IN T17995 GATA-2; Mammalia.
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MX M00086 V$IK1_01.
MX M00087 V$IK2_01.
MX M00088 V$IK3_01.
MX M01169 V$IK_Q5.
MX M07260 V$IK_Q5_01.
MX M00141 V$LYF1_01.
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BS R15115.
BS R15116.
BS R14964.
BS R15117.
BS R26165.
BS R07200.
BS R07201.
BS R07202.
BS R07203.
BS R07204.
BS R07205.
BS R07206.
BS R07207.
BS R07208.
BS R07209.
BS R07210.
BS R15119.
BS R00874.
BS R03518.
BS R03519.
BS R14947.
BS R14948.
BS R21405.
BS R02196.
BS R04718.
BS R14958.
BS R25787.
BS R15128.
BS R59849.
BS R02685.
BS R02982.
BS R14938.
BS R14941.
BS R03509.
BS R03510.
BS R03512.
BS R03513.
BS R24652.
BS R24653.
BS R24655.
BS R24656.
BS R24648.
BS R24649.
BS R24650.
BS R24651.
BS R25978.
BS R21400.
BS R03503.
BS R03504.
BS R14933.
BS R14937.
BS R15118.
BS R14942.
BS R14943.
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DR TRANSPATH: MO000024958.
DR EMBL: L03547; MMIKAROS.
DR UniProtKB: Q03267; IKAR_MOUSE.
XX
RN [1]; RE0001480.
RX PUBMED: 1922043.
RA Lo K., Landau N. R., Smale S. T.
RT LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocytes-specific genes
RL Mol. Cell. Biol. 11:5229-5243 (1991).
RN [2]; RE0006501.
RX PUBMED: 7935426.
RA Hahm K., Ernst P., Lo K., Kim G. S., Turck C., Smale S. T.
RT The lymphoid transcrption factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
RL Mol. Cell. Biol. 14:7111-7123 (1994).
RN [3]; RE0006503.
RX PUBMED: 7585946.
RA Winandy S., Wu P., Georgopoulos K.
RT A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
RL Cell 83:289-299 (1995).
RN [4]; RE0024292.
RX PUBMED: 1439790.
RA Georgopoulos K., Moore D. D., Derfler B.
RT Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.
RL Science 258:808-812 (1992).
RN [5]; RE0026561.
RX PUBMED: 10766745.
RA Koipally J., Georgopoulos K.
RT Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
RL J. Biol. Chem. 275:19594-602 (2000).
XX
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