AC T00505
XX
ID T00505
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DT 21.10.1992 (created); ewi.
DT 22.07.2015 (updated); sla.
CO Copyright (C), QIAGEN.
XX
FA Mef-2A-isoform1
XX
SY A430079H05Rik; MEF-2; MEF-2A; Mef-2a-isoform1; Mef2-Aisoform1; MEF2A; Mef2a-isoform1; myocyte enhancer factor 2A; myocyte enhancer factor 2A isoform 1; myocyte-specific enhancer factor, alternatively spliced exon.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009776 Mef2a.
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HO D-MEF2 (Drosophila).
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CL C0014; MADS.
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SZ 498 AA; 53.7 kDa (cDNA) (calc.).
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SQ MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST
SQ DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCENPDADDYFEHSPLSEDRFIKLNE
SQ DSDFIFKRGPPGFPPQNFSMSVTVPVTSPNPLSDTNPGSSLVSPSLAASSTLAETSMLSP
SQ PPATLHRNVSPGAPQRPPSTGSASGMLSTTDLTVPNGAGNSPVGNGFVNSRASPNLIGNT
SQ GANSLGKVMPTKSPPPPGGGSLGMNSRKPDLRVAIPPSSKGMMPPLSEEEELELNAQRIS
SQ SSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFTSPGMLSLG
SQ QASAWQEHHLGQTTLSSLVAGGQLSQGSNLSINTNQNINIKSEPISPPRDRMTPSGFQHH
SQ HHHPQQQPPPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPANT
SQ EDRESPSVKRMRMDTWVT
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SC conceptually translated from EMBL/GenBank/DDBJ #U30823
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FT 1 60 
SM00432; MADS.
FT 1 61 
PS50066; MADS_BOX_2.
FT 9 59 
PF00319; SRF-type transcription factor (DNA-binding a.
XX
SF in skeletal and heart muscle cells, MEF-2 recognizes the same sequence motif [4];
SF MEF-2 in brain binds to an extended sequence, possible due to interaction with additional factors [4];
SF gene expression in developing brain see for detailed information [9];
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CP myogenic cells, brain [1]; developing brain [9] [1] [9].
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FF involved in myogenesis [6];
FF cooperates with myogenic bHLH factors [6];
FF induces MyoD [6];
FF induced by myogenin [3];
FF cooperates with MyoD through direct interactions and by binding to either MEF-2 sites or to E-box elements [5];
FF expression in cerebellum: begins at postnatal day 6, maintains in adults with highest levels in hippocampus, olfactory bulb, cerebellum [8];
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IN T01537 MRF4; mouse, Mus musculus.
IN T00526 MyoD; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
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MX M00403 V$AMEF2_Q6.
MX M00406 V$HMEF2_Q6.
MX M02024 V$MEF2A_Q6.
MX M00006 V$MEF2_01.
MX M00231 V$MEF2_02.
MX M00232 V$MEF2_03.
MX M00233 V$MEF2_04.
MX M00941 V$MEF2_Q6_01.
MX M07326 V$MEF2_Q6_02.
MX M07424 V$MEF2_Q6_03.
MX M00405 V$MMEF2_Q6.
MX M00026 V$RSRFC4_01.
MX M00407 V$RSRFC4_Q2.
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BS R03583.
BS R03586.
BS R09144.
BS R04212.
BS R02201.
BS R04530.
BS R04804.
BS R04805.
BS R04806.
BS R00244.
BS R03585.
BS R03584.
BS R03589.
BS R03587.
BS R03588.
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DR TRANSPATH: MO000020767.
DR EMBL: U30823; MM30823.
DR UniProtKB: Q60929-1; MEFA_MOUSE.
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RN [1]; RE0000768.
RX PUBMED: 1516833.
RA Yu Y.-T., Breitbart R. E., Smoot L. B., Lee Y., Mahdavi V., Nadal-Ginard B.
RT Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors
RL Genes Dev. 6:1783-1798 (1992).
RN [2]; RE0001228.
RX PUBMED: 2601707.
RA Gossett L. A., Kelvin D. J., Sternberg E. A., Olson E. N.
RT A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes
RL Mol. Cell. Biol. 9:5022-5033 (1989).
RN [3]; RE0001481.
RX PUBMED: 1656214.
RA Cserjesi P., Olson E. N.
RT Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products
RL Mol. Cell. Biol. 11:4854-4862 (1991).
RN [4]; RE0003602.
RX PUBMED: 7559475.
RA Andres V., Cervera M., Mahdavi V.
RT Determination of the consensus binding site for MEF2 expressed in muscle and brain reveals tissue-specific sequence constraints
RL J. Biol. Chem. 270:23246-23249 (1995).
RN [5]; RE0004082.
RX PUBMED: 8548800.
RA Molkentin J. D., Black B. L., Martin J. F., Olson E. N.
RT Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
RL Cell 83:1125-1136 (1995).
RN [6]; RE0004142.
RX PUBMED: 7973707.
RA Kaushal S., Schneider J. W., Nadal-Ginard B., Mahdavi V.
RT Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD
RL Science 266:1236-1240 (1994).
RN [7]; RE0004143.
RX PUBMED: 8524326.
RA Fickett J. W.
RT Quantitative discrimination of MEF2 sites
RL Mol. Cell. Biol. 16:437-441 (1996).
RN [8]; RE0014846.
RX PUBMED: 9013788.
RA Lin X., Shah S., Bulleit R.F.
RT The expression of MEF2 genes is implicated in CNS neuronal differentiation
RL Brain Res. Mol. Brain Res. 42:307-316 (1996).
RN [9]; RE0015071.
RX PUBMED: 7643214.
RA Lyons G.E., Micales B.K., Schwarz J., Martin J.F., Olson E.N.
RT Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
RL J. Neurosci. 15:5727-5738 (1995).
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