AC T01537
XX
ID T01537
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DT 30.07.1995 (created); hiwi.
DT 23.09.2009 (updated); mku.
CO Copyright (C), QIAGEN.
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FA MRF4
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SY herculin; Myf-6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001909 Myf6.
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CL C0010; bHLH.
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SZ 242 AA; 27.0 kDa (cDNA) (calc.).
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SQ MMMDLFETGSYFFYLDGENVTLQPLEVAEGSPLYPGSDGTLSPCQDQMPQEAGSDSSGEE
SQ HVLAPPGLQPPHCPGQCLIWACKTCKRKSAPTDRRKAATLRERRRLKKINEAFEALKRRT
SQ VANPNQRLPKVEILRSAISYIERLQDLLHRLDQQEKMQELGVDPYSYKPKQEILEGADFL
SQ RTCSPQWPSVSDHSRGLVITAKEGGANVDASASSSLQRLSSIVDSISSEERKLPSVEEVV
SQ EK
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SC Swiss-Prot#P15375
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FT 3 93 
PF01586; Myogenic Basic domain.
FT 3 98 
SM00520; BASIC.
FT 93 145 
PS50888; HLH.
FT 94 145 
PF00010; Helix-loop-helix DNA-binding domain.
FT 99 150 
SM00353; finulus.
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CP myogenic cells; skeletal muscle (adult mice ) [1].
CN smooth muscle (adult mice ) [1].
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FF it is transiently expressed after myogenin, before MyoD, and reappears during late stage of skeletal muscle development;
FF during limb bud development, it is expressed just at these late stages [3];
FF Ras proto-oncogene product (Ras p21Val) inhibits myogenic differentiation via targeting the basic domain of MRF4, but without affecting its DNA-binding capability [4];
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IN T00505 Mef-2A-isoform1; mouse, Mus musculus.
IN T01005 MEF-2A-isoform1; human, Homo sapiens.
IN T01784 MEF-2A; clawed frog, Xenopus laevis.
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MX M00804 V$E2A_Q2.
MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M03831 V$MRF4_Q3.
MX M02781 V$MYF6_03.
MX M02885 V$MYF6_04.
MX M00929 V$MYOD_Q6_01.
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DR TRANSPATH: MO000025749.
DR EMBL: M30499;
DR EMBL: X59060;
DR UniProtKB: P15375;
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RN [1]; RE0002421.
RX PUBMED: 2300571.
RA Miner J. H., Wold B. J.
RT Herculin, a fourth member of the MyoD family of myogenic regulatory genes
RL Proc. Natl. Acad. Sci. USA 87:1089-1093 (1990).
RN [2]; RE0002987.
RX PUBMED: 1328851.
RA Mak K.-L., To R. Q., Kong Y., Konieczny S. F.
RT The MRF4 activation domain is required to induce muscle-specific gene expression
RL Mol. Cell. Biol. 12:4334-4346 (1992).
RN [3]; RE0003272.
RX PUBMED: 2045411.
RA Bober E., Lyons G. E., Braun T., Cossu G., Buckingham M., Arnold H. H.
RT The muscle regulatory gene, myf-6, has a biphasic pattern of expression during early mouse development
RL J. Cell Biol. 113:1255-1265 (1991).
RN [4]; RE0005808.
RX PUBMED: 7565669.
RA Kong Y., Johnson S. E., Taparowsky E. J., Konieczny S. F.
RT Ras p21 (Val) inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors
RL Mol. Cell. Biol. 15:5205-5213 (1995).
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