AC T01784
XX
ID T01784
XX
DT 24.04.1996 (created); ewi.
DT 26.07.2004 (updated); cch.
CO Copyright (C), QIAGEN.
XX
FA MEF-2A
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SY MEF-2; MEF-2 (516 AA); MEF-2A; SL-2.
XX
OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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HO D-MEF2 (Drosophila).
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CL C0014; MADS.
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SZ 516 AA; 56.4 kDa (cDNA) (calc.).
XX
SQ MGRRKIQITRIMDDRNKQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYAST
SQ DMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDDQRYFEEETFSKLIEDSDFV
SQ FKRDPALNKKENRGCDSPDPDGSYVLTPHTEEKYKKINEEFDNMMRSHKISPGLPQQTFP
SQ MSVTVPVSNPNTLPYSSPGNTMVTASLAASASLTDARMLSPPPTTLHRNVFPQGYPSEPP
SQ STGNAGVMLCSSDLSVPNGAGTSPVGNGFVNPRASPSHLGPTGGNVLGKVMPTKSPPPPG
SQ GNLVMNSRKPDLRVVIPPSSKGMMPPLNTQRVTSSQGTQPLATPIVSVATPSLAPQGLIY
SQ SAMPTAYNTDYPLTSADLSMLQGFNSPGILPLGQVSAWQQHHVGQAALSSFVATGQLSQG
SQ SNLSINTNQNINIKSEPISPPRDRITPSGFQSHQHHQHQPRPEMDSLSSSSSSYDGSDRE
SQ DVRNDFHSPIGLGRPANNEDRDSPSVKRMRMDAWVT
XX
SC conceptually translated from EMBL/GenBank/DDBJ #Z19123
XX
FT 1 60 
SM00432; MADS.
FT 1 61 
PS50066; MADS_BOX_2.
FT 9 59 
PF00319; SRF-type transcription factor (DNA-binding a.
FT 37 455 
PF00478; IMP dehydrogenase / GMP reductase domain.
XX
SF binding preference for A/T-rich sequences causes overlapping binding with TFIID [3];
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CP (embryo): in stage 14 paraxial mesoderm, in stage 14 and 22: differentiating somites [4];(adult): high in skeletal muscle, heart, lower in brain, spleen, kidney [1] [4] [1].
CN (embryo): in stage 14 notochord [4]; (adult:) ovary, stomach, liver [1] [4] [1].
XX
FF induces MyoD [3];
FF induced by MyoD and Myf-5 [2];
FF embryonic stage 15 [2];
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IN T01537 MRF4; mouse, Mus musculus.
IN T00526 MyoD; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
IN T00798 Spt15p; yeast, Saccharomyces cerevisiae.
XX
BS R03583.
BS R03586.
BS R04212.
BS R02201.
BS R00244.
BS R03585.
BS R03584.
BS R03589.
BS R03587.
BS R03588.
BS R08479.
BS R09446.
XX
DR TRANSPATH: MO000025921.
DR EMBL: Z19123;
DR UniProtKB: Q03414-1;
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RN [1]; RE0004083.
RX PUBMED: 1281451.
RA Chambers A. E., Kotecha S., Towers N., Mohun T. J.
RT Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis
RL EMBO J. 11:4981-4991 (1992).
RN [2]; RE0004084.
RX PUBMED: 7926733.
RA Chambers A. E., Logan M., Kotecha S., Towers N., Sparrow D., Mohun T. J.
RT The RSRF/MEF2 protein SL1 regulates cardiac muscle-cpecific transcription of a myosin light-chain gene in Xenopus embryos
RL Genes Dev. 8:1324-1334 (1994).
RN [3]; RE0004141.
RX PUBMED: 8264638.
RA Leibham D., Wong M.-W., Cheng T.-C., Schroeder S., Weil P. A., Olson E. N., Perry M.
RT Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter
RL Mol. Cell. Biol. 14:686-699 (1994).
RN [4]; RE0015047.
RX PUBMED: 7813786.
RA Wong M.W., Pisegna M., Lu M.F., Leibham D., Perry M.
RT Activation of Xenopus MyoD transcription by members of the MEF2 protein family
RL Dev. Biol. 166:683-695 (1994).
XX
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