AC T01066
XX
ID T01066
XX
DT 24.02.1994 (created); ewi.
DT 21.02.2000 (updated); ewi.
CO Copyright (C), QIAGEN.
XX
FA runt
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SY runt.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
CL C0029; runt.
XX
SZ 509 AA; 53.3 kDa (cDNA) (calc.).
XX
SQ MHLPAGPTMVANNTQVLAAAAAAAAAAAAVAQGPGPQQSSNATTASAIAINPAQSLANTS
SQ THSASSTGSSTPDLSTNNTSSSSNATTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQT
SQ GSPSILCSALPNHWRSNKSLPGAFKVIALDDWPDGTLVSIKCGNDENYCGELRNCTTTMK
SQ NQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSYGYP
SQ HPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSV
SQ ATSSSSAVQPSEYPHPAAAVAAAAGQPSAMMPSPPGAAPATPYAIPQFPFNHVAAAAAAK
SQ AATPHAFHPYNFAAAAGLRARNAALHHQSEPVHVSPASSRPSSSSPTQQHVLLKLNTSIE
SQ TSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRMRCDLKAPSSMKPLYHESGPGA
SQ VANSRQPSPETTTKIKSAAVQQKTVWRPY
XX
SC Swiss-Prot#P22814
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FT 41 506 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 103 237 
PF00853; Runt domain.
FT 105 233 
PS51062; RUNT.
XX
FF segmentation gene [1];
FF act as a direct repressor of hairy, albeit two stripes [2];
FF repress even-skipped (eve) gene expression [2];
FF repressed by promoter-bound Hairy [2];
FF interaction with Groucho is important for the VWRPY-dependent repression activities of runt [3];
FF a second repression activity is independent of this conserved C-terminal sequence [3];
XX
IN T02222 Bgb; fruit fly, Drosophila melanogaster.
IN T02221 Bro; fruit fly, Drosophila melanogaster.
IN T02451 groucho; fruit fly, Drosophila melanogaster.
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MX M02360 I$RUNBGB_01.
XX
DR TRANSPATH: MO000045971.
DR EMBL: X56432; DMRUNTR.
DR UniProtKB: P22814; RUNT_DROME.
DR FLYBASE: FBgn0003300; run.
XX
RN [1]; RE0002540.
RX PUBMED: 8341710.
RA Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K., Ito Y.
RT PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
RL Proc. Natl. Acad. Sci. USA 90:6859-6863 (1993).
RN [2]; RE0006086.
RX PUBMED: 9003784.
RA Jimenez G., Pinchin S. M., Ish-Horowicz D.
RT In vitro interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters
RL EMBO J. 15:7088-7098 (1996).
RN [3]; RE0006216.
RX PUBMED: 9271433.
RA Aronson B. D., Fisher A. L., Blechman K., Caudy M., Gergen J. P.
RT Groucho-dependent and -independent repression activities of runt domain proteins
RL Mol. Biol. Cell 17:5581-5587 (1997).
XX
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