AC T01652
XX
ID T01652
XX
DT 02.02.1996 (created); ewi.
DT 05.02.2013 (updated); prb.
CO Copyright (C), QIAGEN.
XX
FA HES-5
XX
SY hairy and enhancer of split 5 (Drosophila); Hes5.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014489 Hes5.
XX
HO Hairy, E(spl) proteins.
XX
CL C0010; bHLH; 1.2.4.1.5.
XX
SF binds to N-box, but not to E-box elements [1];
SF heterodimerization with E47 is only 5% as effective as homodimerization [1];
XX
CP nervous system: CNS (embryonic d16.5), ventricular zones of embryonic brain vesicles, outer layer of neural retina; postnatal d6: eye [1].
CN embryonal d18: adrenal, heart, gastrointestinal tract, kidney, liver, muscle, skin, spinal cord; adult eye, kidney, liver [1].
EX adrenal gland (right and left),,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX alimentary tract,,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX brain,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,adult; low; Northern blot; total RNA; [1].
EX brain,,,adult; medium; RNAse protection assay; total RNA; [1].
EX brain,,,witschi 34; high; RNAse protection assay; total RNA; [1].
EX central nervous system,,,Witschi 33; high; Northern blot; total RNA; [1].
EX cerebellum,Purkinje cell,,adult; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX diencephalon,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX dorsal root ganglion,,,witschi 34; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX eye and related structure (right and left),,,Witschi 35 postnatal; low; Northern blot; total RNA; [1].
EX eye and related structure (right and left),,,adult; none; Northern blot; total RNA; [1].
EX eye and related structure (right and left),,,witschi 34; high; Northern blot; total RNA; [1].
EX fourth ventricle,,,witschi 34; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [1].
EX kidney (right and left),,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX lateral ventricles (right and left),,,witschi 34; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX liver,,,adult; none; Northern blot; total RNA; [1].
EX liver,,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX mesencephalon,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX metencephalon,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX muscles,,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX myelencephalon,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX olfactory bulb,,,adult; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX outer nuclear layer of retina,,,witschi 34; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rat, Rattus norvegicus,,,Witschi 28; high; Northern blot; total RNA; [1].
EX skin,,,witschi 34; none; RNAse protection assay; total RNA; [1].
EX spinal cord,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX spinal cord,,,witschi 34; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX spinal cord,,,witschi 34; very low; RNAse protection assay; total RNA; [1].
EX telencephalon,,,Witschi 32; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX third ventricle,,,witschi 34; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
XX
FF repressor through N-box elements [1];
FF weak effect at E boxes by inhibition of E47;
FF may be involved in neural development, decreases sharply when neural differentiation proceeds [1];
FF specific expression of the HES-5 gene in neural precursor cells is driven by the promoter, in particular by multiple GC stretches [2];
XX
IN T00005 Ac; fruit fly, Drosophila melanogaster.
IN T00207 E47; human, Homo sapiens.
IN T00674 E47; rat, Rattus norvegicus.
IN T01652 HES-5; rat, Rattus norvegicus.
IN T00484 MASH-1; rat, Rattus norvegicus.
XX
BS R16657.
XX
DR TRANSPATH: MO000025839.
DR UniProtKB: Q03062;
XX
RN [1]; RE0003682.
RX PUBMED: 1400497.
RA Akazawa C., Sasai Y., Nakanishi S., Kageyama R.
RT Molecular characterization of a rat negative regulator with a basic helix-loop- helix structure predominantly expressed in the developing nervous system
RL J. Biol. Chem. 267:21879-21885 (1992).
RN [2]; RE0003795.
RX PUBMED: 7836401.
RA Takebayashi K., Akazawa C., Nakanishi S., Kageyama R.
RT Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5
RL J. Biol. Chem. 270:1342-1349 (1995).
XX
//