AC T01945
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ID T01945
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DT 18.11.1996 (created); ewi.
DT 15.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA NFATc1
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SY NF-AT2; NF-ATc1; NFAT2; NFATC; NFATC1; Nuclear Factor of Activated T-cells c (NF-AT2).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005372 NFATC1; HGNC: NFATC1.
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CL C0052; REL/NFAT; 6.1.3.0.1.
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SF six different splice variants are known;
SF binds DNA as a monomer;
SF solution structure of the binary NFATc1-DNA complex has been reported, DNA binding induces the folding of key structural elements [10];
SF orientation of the NFAT DBD in the binary complex is different from that in the ternary complex NFAT-AP1-DNA [10];
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CP Th1, Th2, thymocytes.
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FF activator;
FF inducible in T-cells upon T-cell activation, by TPA and ionomycin, no direct substrate for calcineurin [1];
FF functionally cooperates and forms complexes with AP-1;
FF regulates gene transcription synergistically with Egr-1 [6] [5];
FF may functionally cooperate with IRF-4 [7];
FF binding sites are often overlap with NF-kappaB binding sites [2];
FF activates the human cox-2 gene in T-cells in response to calcineurin and Cot kinase [8] [9];
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IN T10873 c-Ets-1; Mammalia.
IN T08988 Elf-1-isoform1; human, Homo sapiens.
IN T08572 GATA-3; mouse, Mus musculus.
IN T05351 PPARgamma; human, Homo sapiens.
IN T10037 PU.1; Mammalia.
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MX M07264 V$NFAT2_Q4.
MX M01718 V$NFAT2_Q5.
MX M07606 V$NFAT2_Q5_01.
MX M07608 V$NFAT_Q3.
MX M00935 V$NFAT_Q4_01.
MX M00302 V$NFAT_Q6.
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BS R29672.
BS R29954.
BS R00702.
BS R08181.
BS R30033.
BS R30062.
BS R13414.
BS R28018.
BS R24088.
BS R08184.
BS R29670.
BS R00931.
BS R24997.
BS R27348.
BS R68306.
BS R08170.
BS R29645.
BS R24474.
BS R59910.
BS R56100.
BS R29899.
BS R41849.
BS R14626.
BS R14627.
BS R20468.
BS R56045.
BS R29724.
BS R14705.
BS R29735.
BS R61039.
BS R69250.
BS R69251.
BS R02348.
BS R02349.
BS R05049.
BS R05051.
BS R05053.
BS R24087.
BS R05080.
BS R05097.
BS R24711.
BS R29658.
BS R29799.
BS R29800.
BS R58748.
BS R58749.
BS R29590.
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DR TRANSPATH: MO000020760.
DR TRANSCOMPEL: C00157.
DR TRANSCOMPEL: C00351.
DR TRANSCOMPEL: C00356.
DR TRANSCOMPEL: C00384.
DR TRANSCOMPEL: C00385.
DR TRANSCOMPEL: C00495.
DR TRANSCOMPEL: C00647.
DR TRANSCOMPEL: C00648.
DR UniProtKB: O95644; NFC1_HUMAN.
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RN [1]; RE0004486.
RX PUBMED: 8202141.
RA Northrop J. P., Ho S. N., Chen L., Thomas D. J., Timmerman L. A., Nolan G. P., Admon A., Crabtree G. R.
RT NF-AT components define a family of transcription factors targeted in T-cell activation
RL Nature 369:497-502 (1994).
RN [2]; RE0013419.
RX PUBMED: 9374532.
RA Sica A., Dorman L., Viggiano V., Cippitelli M., Ghosh P., Rice N., Young H. A.
RT Interaction of NF-kappaB and NFAT with the interferon-gamma promoter
RL J. Biol. Chem. 272:30412-304120 (1997).
RN [3]; RE0016682.
RX PUBMED: 9094628.
RA Bassuk A. G., Anandappa R. T., Leiden J. M.
RT Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.
RL J. Virol. 71:3563-3573 (1997).
RN [4]; RE0017781.
RX PUBMED: 11287617.
RA Kaminuma O., Deckert M., Elly C., Liu Y. C., Altman A.
RT Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
RL Mol. Cell. Biol. 21:3126-3136 (2001).
RN [5]; RE0017818.
RX PUBMED: 10508276.
RA Li-Weber M., Laur O., Krammer P. H.
RT Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation.
RL Eur. J. Immunol. 29:3017-3027 (1999).
RN [6]; RE0022849.
RX PUBMED: 9756940.
RA Decker E. L., Skerka C., Zipfel P. F.
RT The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells.
RL J. Biol. Chem. 273:26923-26930 (1998).
RN [7]; RE0022878.
RX PUBMED: 12374808.
RA Hu C. M., Jang S. Y., Fanzo J. C., Pernis A. B.
RT Modulation of T cell cytokine production by interferon regulatory factor-4.
RL J. Biol. Chem. 277:49238-49246 (2002).
RN [8]; RE0023916.
RX PUBMED: 11356833.
RA de Gregorio R., Iniguez M. A., Fresno M., Alemany S.
RT Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells.
RL J. Biol. Chem. 276:27003-27009 (2001).
RN [9]; RE0023917.
RX PUBMED: 10816557.
RA Iniguez M. A., Martinez-Martinez S., Punzon C., Redondo J. M., Fresno M.
RT An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes.
RL J. Biol. Chem. 275:23627-23635 (2000).
RN [10]; RE0023937.
RX PUBMED: 9506523.
RA Zhou P., Sun L. J., Doetsch V., Wagner G., Verdine G. L.
RT Solution structure of the core NFATC1/DNA complex.
RL Cell 92:687-696 (1998).
RN [11]; RE0030092.
RX PUBMED: 12560487.
RA Decker E. L., Nehmann N., Kampen E., Eibel H., Zipfel P. F., Skerka C.
RT Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
RL Nucleic Acids Res. 31:911-21 (2003).
RN [12]; RE0055156.
RX PUBMED: 18772129.
RA Klein-Hessling S., Bopp T., Jha M. K., Schmidt A., Miyatake S., Schmitt E., Serfling E.
RT Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter.
RL J. Biol. Chem. 283:31030-31037 (2008).
RN [13]; RE0070940.
RX PUBMED: 21148296.
RA Wang Q., Zhou Y., Jackson L. N., Johnson S. M., Chow C. W., Evers B. M.
RT Nuclear factor of activated T cells (NFAT) signaling regulates PTEN expression and intestinal cell differentiation.
RL Mol. Biol. Cell 22:412-420 (2011).
RN [14]; RE0022703.
RX PUBMED: 10652349.
RA Porter C. M., Havens M. A., Clipstone N. A.
RT Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization.
RL J. Biol. Chem. 275:3543-3551 (2000).
RN [15]; RE0022711.
RX PUBMED: 12351631.
RA Sheridan C. M., Heist E. K., Beals C. R., Crabtree G. R., Gardner P.
RT Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
RL J. Biol. Chem. 277:48664-48676 (2002).
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