AC T08988
XX
ID T08988
XX
DT 05.06.2006 (created); kau.
CO Copyright (C), QIAGEN.
XX
FA Elf-1-isoform1
XX
SY E74-like factor 1; Elf-1; ETS-related transcription factor ELF-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002978 ELF1; HGNC: Elf1.
XX
CL C0016; ETS.
XX
SZ 619 AA; 67.5 kDa (cDNA) (calc.).
XX
SQ MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM
SQ ITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRI
SQ NNNIFSSPEDDMVVAPVTHVSVTLDGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKT
SQ KPPRPDSPATTPNISVKKKNKDGKGNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKL
SQ VDSKAVSRLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYIN
SQ DEDPSSSIESSDPSLSSSATSNRNQTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVE
SQ VAQPSEVLRTVQPTQSPYPTQLFRTVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRT
SQ IQAPTQVPVVVSPRNQQLHTVTLQTVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVL
SQ KENVMLQSQKAGSPPSIVLGPAQVQQVLTSNVQTICNGTVSVASSPSFSATAPGVTFSPR
SQ SSQLVAHPPGTVITSVIKTQETKTLTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSN
SQ GFTSQVAMKQNELLEPNSF
XX
SC Swiss-Prot#P32519
XX
FT 21 72 
Rb binding domain [1].
FT 23 577 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 207 292 
PF00178; Ets-domain.
FT 207 294 
SM00413; etsneu2.
FT 208 290 
PS50061; ETS_DOMAIN_3.
FT 210 280 
PS50140; HSF_ETS.
XX
IN T08587 c-Jun; mouse, Mus musculus.
IN T10058 Fli-1; mouse, Mus musculus.
IN T08571 GATA-2-isoform1; human, Homo sapiens.
IN T09925 GATA-3; human, Homo sapiens.
IN T08590 JunB; mouse, Mus musculus.
IN T08536 JunD; mouse, Mus musculus.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T01945 NFATc1; human, Homo sapiens.
XX
MX M01266 V$ELF1_Q5.
MX M00746 V$ELF1_Q6.
MX M02053 V$ELF_02.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R25964.
BS R14808.
BS R00930.
BS R12017.
BS R28506.
BS R28509.
XX
DR TRANSPATH: MO000082433.
DR EMBL: M82882;
DR UniProtKB: P32519;
XX
RN [1]; RE0002718.
RX PUBMED: 8493578.
RA Wang C.-Y., Petryniak B., Thompson C. B., Kaelin W. G., Leiden J. M.
RT Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein
RL Science 260:1330-1335 (1993).
RN [2]; RE0003086.
RX PUBMED: 1545787.
RA Thompson C. B., Wang C.-Y., Ho I-C., Bohjanen P. R., Petryniak B., June C. H., Miesfeldt S., Zhang L., Nabel G. J., Karpinski B., Leiden J. M.
RT cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1
RL Mol. Cell. Biol. 12:1043-1053 (1992).
RN [3]; RE0004628.
RX PUBMED: 8441422.
RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B.
RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
RL Mol. Cell. Biol. 13:1911-1919 (1993).
RN [4]; RE0005363.
RX PUBMED: 1527846.
RA Leiden J. M., Wang C. Y., Petryniak B., Markovitz D. M., Nabel G. J., Thompson C. B.
RT A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells
RL J. Virol. 66:5890-5897 (1992).
RN [5]; RE0016682.
RX PUBMED: 9094628.
RA Bassuk A. G., Anandappa R. T., Leiden J. M.
RT Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.
RL J. Virol. 71:3563-3573 (1997).
RN [6]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [7]; RE0017450.
RX PUBMED: 11210123.
RA Nishiyama C., Takahashi K., Nishiyama M., Okumura K., Ra C., Ohtake Y., Yokota T.
RT Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1.
RL Biosci. Biotechnol. Biochem. 64:2601-2607 (2000).
RN [8]; RE0017525.
RX PUBMED: 8756667.
RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A.
RT Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1
RL Mol. Cell. Biol. 16:5091-5106 (1996).
RN [9]; RE0023642.
RX PUBMED: 12065417.
RA Gottgens B., Nastos A., Kinston S., Piltz S., Delabesse E. C., Stanley M., Sanchez M. J., Ciau-Uitz A., Patient R., Green A. R.
RT Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
RL EMBO J. 21:3039-3050 (2002).
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