AC T03236
XX
ID T03236
XX
DT 10.04.2000 (created); sur.
DT 08.06.2001 (updated); ulg.
CO Copyright (C), QIAGEN.
XX
FA CBP
XX
SY CBP/p300; CREB-binding protein; dCBP.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
SZ 3190 AA; 331.9 kDa (cDNA) (calc.).
XX
SQ MMADHLDEPPQKRVKMDPTDISYFLEENLPDELVSSNSGWSDQLTGGAGGGNGGGGASGV
SQ TTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGSG
SQ TGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQ
SQ GGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVLTNSVGGGMGGMV
SQ NHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQ
SQ HMLRGPHLMGASGGAGGPGNGPGGGGPRMQNPNMQMTQLNSLPYGVGQYGGPGGGNNPQQ
SQ QQQQQQQQLLAQQMAQRGGVVPGMPRGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQ
SQ MLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTV
SQ AGVPAVAGGGAGGAVQSSGPGGANRDVPDDRKRQIQQQLMLLLHAHKCNRRENLNPNREV
SQ CNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSV
SQ FQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVG
SQ GKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQ
SQ QELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDV
SQ NSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSVNV
SQ GGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVL
SQ MPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLV
SQ QAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKR
SQ LKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPL
SQ QSCIHPSISPMGGVMPPQQLRPQGPPGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNML
SQ ALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQ
SQ QQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQ
SQ QQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPG
SQ TGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNSSSANNNPPSVSSLMQQPLSNRPGTP
SQ PYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGT
SQ PLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTST
SQ SSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSI
SQ KQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKI
SQ KTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLV
SQ PEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEI
SQ VKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNPKTSRVYRYCTKLSEVFEAE
SQ IDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQ
SQ KCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWL
SQ DSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHI
SQ RVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGS
SQ ECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEG
SQ DDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPY
SQ FEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAK
SQ KSNKSKAAQRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDP
SQ DPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKT
SQ AVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQ
SQ RCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNC
SQ EEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVV
SQ SGGVPVVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPH
SQ PHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPVMNRPMGGA
SQ GPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMS
SQ MDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPN
SQ QLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQ
SQ KIKNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNG
SQ PQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGP
SQ GGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYP
SQ QRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTVPGGDQY
SQ SMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQQ
SQ MMQVAMPNANAQNPSAVVGGPNAQVMVRRRRISAAAADAIGPLVAAYSLPAANAIATFGS
SQ IATCCSIRLA
XX
SC translated from EMBL #U88570
XX
FT 152 2187 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 156 690 
arm C domain [1].
FT 508 593 
PF02135; TAZ zinc finger.
FT 508 594 
PS50134; ZF_TAZ.
FT 508 594 
SM00551; ZnF_TAZ.
FT 938 1017 
PS50952; KIX.
FT 938 1018 
PF02172; KIX domain.
FT 1221 1806 
SM00297; bromo_6.
FT 1675 2510 
HAT (histone acetyl transferase) domain [1].
FT 1702 1792 
PF00439; Bromodomain.
FT 1715 1787 PS50014; BROMODOMAIN_2.
FT 1793 1853 PF06001; Domain of Unknown Function (DUF902).
FT 1938 2174 PF06010; Domain of Unknown Function (DUF906).
FT 2240 2507 CBP2 domain [1].
FT 2329 2370 PF00569; Zinc finger, ZZ type.
FT 2329 2372 PS50135; ZF_ZZ_2.
FT 2329 2372 SM00291; zz_5.
FT 2391 2470 PF02135; TAZ zinc finger.
FT 2392 2471 SM00551; ZnF_TAZ.
FT 2392 2473 PS50134; ZF_TAZ.
FT 2477 2486 PF00904; Involucrin repeat.
FT 2920 2929 PF00904; Involucrin repeat.
FT 3072 3081 PF00904; Involucrin repeat.
FT 3091 3100 PF00904; Involucrin repeat.
XX
SF acts as a negative regulator in the wingless pathway since it antagonizes Armadillo [1];
XX
FF the CBP2 domain binds to Drosophila TCF and mouse LEF-1;
FF CBP contains a HAT (histone acetyl transferase) domain which acetylates special lysine residues in Drosophila TCF-A and TCF-B and lowers the affinity for Armadillo (the TCF coactivator);
FF thus it interacts as an repressor of TCF transcription factors [1];
FF C-terminal domain (AA2240-AA2608) interacts with MH2 domain of Mad (AA219-AA455) T04378 [2];
XX
IN T00930 LEF-1; mouse, Mus musculus.
IN T02922 TCF-A; fruit fly, Drosophila melanogaster.
IN T02924 TCF-B; fruit fly, Drosophila melanogaster.
XX
DR TRANSPATH: MO000019108.
DR EMBL: U88570; DMU88570.
DR UniProtKB: O01368; O01368.
XX
RN [1]; RE0014226.
RX PUBMED: 9774110.
RA Waltzer L., Bienz M.
RT Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
RL Nature 395:521-525 (1998).
RN [2]; RE0016258.
RX PUBMED: 10075933.
RA Waltzer L., Bienz M.
RT A function of CBP as a transcriptional co-activator during Dpp signalling.
RL EMBO J. 18:1630-1641 (1999).
XX
//