DT 23.11.2000 (created); rio.
DT 20.11.2007 (updated); sba.
CO Copyright (C), QIAGEN.
SY gastrulation and brain specific homeobox protein 2.
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
GE G002047 GBX2; HGNC: GBX2.
CL C0006; homeo; 188.8.131.52.2.
SF amino acid sequence is 100% identical to murine Gbx-2 and T04020 and 97% identical to chicken Gbx2 T04021 ;
SF located on the same chromosome as En-1T02015 but not on the same locus like it is the case in mouse ;
CP (cell lines:) hematopoietic cell lines K562 and SKW64 .
EX brain,,,fetal-3; high; Northern blot; mRNA (poly-A); .
EX somatic tissue,,,fetal-2; low; Northern blot; mRNA (poly-A); .
FF probably involved in CNS development ;
MX M01382 V$GBX2_01.
MX M04324 V$GBX2_04.
DR TRANSPATH: MO000027928.
DR UniProtKB: P52951;
RN ; RE0015345.
RX PUBMED: 8838315.
RA Lin X., Swaroop A., Vaccarino F. M., Murtha M. T., Haas M., Ji X., Ruddle F. H., Leckman J. F.
RT Characterization and sequence analysis of the human homeobox-containing gene GBX2
RL Genomics 31:335-342 (1996).
RN ; RE0015348.
RX PUBMED: 9346236.
RA Kowenz-Leutz E., Herr P., Niss K., Leutz A.
RT The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation
RL Cell 91:185-195 (1997).
RN ; RE0015373.
RX PUBMED: 7903253.
RA Matsui T., Hirai M., Hirano M., Kurosawa Y.
RT The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans
RL FEBS Lett. 336:107-110 (1993).