AC T04255
XX
ID T04255
XX
DT 26.01.2001 (created); rio.
DT 28.02.2012 (updated); grs.
CO Copyright (C), QIAGEN.
XX
FA NKX3A
XX
SY Nkx-3.1; NKX3.1; NKX3A.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004029 NKX3-1; HGNC: NKX3-1.
XX
HO NK-3 T03612 Drosophila.
XX
CL C0006; homeo; 3.1.2.16.1.1.
XX
SZ 234 AA; 26.2 kDa (cDNA) (calc.).
XX
SQ MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGGRTSSQRQRDPEPEPEP
SQ EPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSYLLDSENTSGALPRLPQTP
SQ KQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTK
SQ RKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYPYYPYLYCVGSWSPAFG
XX
SC translated from EMBL #U91540
XX
FT 122 182 
PS50071; HOMEOBOX_2.
FT 124 186 
SM00389; HOX_1.
FT 125 181 
PF00046; Homeobox domain.
XX
SF 78% homeo domain identity to NK-3/Tinman T03612 of Drosophila [1];
SF androgen responsive expression [1];
SF androgens and estradiol but not progesterone can increase expression [2];
SF at least 5 different splice variants: NKX3A T04255, NKX3A v1T04287, NKX3A v2 T04288, NKX3A v3 T04289 and NKX3A v4 T04290 [2];
SF untypical TAAGTA binding consensus that has not been reported for any other NK class homeodomain factor [3];
XX
CP (cell lines:) LNCaP [1].
CN (cell lines:) PC3, DU-145, FS4, HuPBL, DAOY, BHM22, 8392, HeLa, SW480, RT-4, HTB-44, OVCAR-3, CATES-1B [1].
EX colon,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX ovary (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; low; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; none; Northern blot; mRNA (poly-A); [1].
XX
FF involved in androgen-driven differentiation of prostatic tissue [1];
FF may have important regulatory roles during prostate cancer progression [2];
FF transcriptional repressor [3];
XX
IN T09343 SRF; human, Homo sapiens.
XX
MX M00451 V$NKX3A_01.
MX M01383 V$NKX3A_02.
MX M03833 V$NKX3A_Q3.
XX
BS R10331.
BS R10332.
BS R10333.
BS R10334.
BS R10335.
BS R10336.
BS R10337.
BS R10338.
BS R10339.
BS R10340.
BS R10341.
BS R10342.
BS R10343.
BS R10344.
BS R10345.
BS R10346.
BS R10347.
BS R10348.
BS R10349.
XX
DR TRANSPATH: MO000028121.
DR EMBL: U91540;
DR UniProtKB: Q99801-1;
XX
RN [1]; RE0015663.
RX PUBMED: 9226374.
RA He W. W., Sciavolino P. J., Wing J., Augustus M., Hudson P., Meissner P. S., Curtis R. T., Shell B. K., Bostwick D. G., Tindall D. J., Gelmann E. P., Abate-Shen C., Carter K. C.
RT A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer
RL Genomics 43:69-77 (1997).
RN [2]; RE0015706.
RX PUBMED: 11137288.
RA Korkmaz K. S., Korkmaz C. G., Ragnhildstveit E., Kizildag S., Pretlow T. G., Saatcioglu F.
RT Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens
RL Gene 260:25-36 (2000).
RN [3]; RE0016763.
RX PUBMED: 10871372.
RA Steadman D. J., Giuffrida D., Gelmann E. P.
RT DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1
RL Nucleic Acids Res. 28:2389-2395 (2000).
RN [4]; RE0062639.
RX PUBMED: 18296735.
RA Zhang Y., Fillmore R. A., Zimmer W. E.
RT Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor.
RL Exp. Biol. Med. (Maywood) 233:297-309 (2008).
XX
//