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AC T04325
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ID T04325
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DT 14.02.2001 (created); rio.
DT 02.04.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Nkx2-3
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SY Nkx-2.3; Nkx2.3; NKX2C.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004541 Nkx2-3.
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HO tinman T03612 (Drosophila).
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CL C0006; homeo; 3.1.2.17.1.
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SF in contrast to chicken and Xenopus expression was not observed in the developing heart or neural tube [2];
SF Nkx2-3 -/- phenotype showed growth retardation, 50% died within 21 days (probably due to malabsorption crisis), delayed villus formation in small intestine, severely perturbed epithelium architecture of the small intestine, diarrhea and steatorrhea, increased proliferation and migration rates of enterocytes, abnormalities of gut-associated lymphoid tissue, reduced/lacked spleens and downregulation of BMP2, BMP4 and MadCAM-1 but not of other gut markers like FOXL1 T02417, Cdx-1 T01999, Cdx-2 T02002, shh and E-cadherin [1] [3];
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CP (pre- and postnatal:) gut mesenchyme, regions of branchial arches, tongue epithelium, jaws, tooth anlagen [2].
EX bone marrow,,,adult; low; Northern blot; RNA (undefined); [3].
EX heart,,,adult; low; Northern blot; RNA (undefined); [3].
EX liver,,,adult; low; Northern blot; RNA (undefined); [3].
EX spleen,,,adult; high; Northern blot; RNA (undefined); [3].
EX thymus,,,adult; low; Northern blot; RNA (undefined); [3].
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FF essential for normal development and functions of the small intestine and spleen [1] [3];
FF MadCAM-1 (mucosal addressin cell adhesion molecule-1) is a potential target gene that controls leucocyte homing in specialized endothelia [1];
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MX M01457 V$NKX23_01.
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DR TRANSPATH: MO000028183.
DR UniProtKB: P97334;
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RN [1]; RE0015763.
RX PUBMED: 10926756.
RA Wang C. C., Biben C., Robb L., Nassir F., Barnett L., Davidson N. O., Koentgen F., Tarlinton D., Harvey R. P.
RT Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera
RL Dev. Biol. 224:152-167 (2000).
RN [2]; RE0015766.
RX PUBMED: 9142493.
RA Pabst O., Schneider A., Brand T., Arnold H. H.
RT The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development
RL Dev. Dyn. 209:29-35 (1997).
RN [3]; RE0015767.
RX PUBMED: 10207146.
RA Pabst O., Zweigerdt R., Arnold H. H.
RT Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen
RL Development 126:2215-2225 (1999).
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