AC T04336
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ID T04336
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DT 20.02.2001 (created); rio.
DT 15.04.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Nkx2-8
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SY Nkx-2.8; NKX2-8; NKX2G.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004559 NKX2-8; HGNC: NKX2-8.
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HO tinman T03612 (Drosophila).
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CL C0053; NK-2/Nkx; 3.1.2.15.2.
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SF most closely related to TTF-1 T00857 and NKX2B T04337 [2];
SF may be the alpha-fetoprotein (AFP) regulator PCF [2] [1];
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CP (cell lines:) hepatocarcinoma cell lines HepG2, HuH7 and Clone 2 [2].
CN (cell lines:) R7451 [2].
EX blood,,,adult; very low; RT-PCR; mRNA (poly-A); [2].
EX liver,,,adult; none; RT-PCR; mRNA (poly-A); [2].
EX liver,,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX liver,,,fetal; low; RT-PCR; mRNA (poly-A); [2].
EX liver,,,fetal; very low; Northern blot; mRNA (poly-A); [2].
EX lung (right and left),,,adult; none; Northern blot; mRNA (poly-A); [2].
EX lung (right and left),,,adult; very low; RT-PCR; mRNA (poly-A); [2].
EX spleen,,,adult; none; Northern blot; mRNA (poly-A); [2].
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FF transcriptional activator [2];
FF associated with liver development and alpha-fetoprotein (AFP) expression [2];
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MX M04412 V$NKX28_01.
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BS R14700.
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DR TRANSPATH: MO000028194.
DR UniProtKB: O15522;
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RN [1]; RE0009815.
RX PUBMED: 7523856.
RA Wen P., Locker J.
RT A novel hepatocytic transcription factor that binds the alpha-fetoprotein promoter-linked coupling element
RL Mol. Cell. Biol. 14:6616-6626 (1994).
RN [2]; RE0015773.
RX PUBMED: 9446603.
RA Apergis G. A., Crawford N., Ghosh D., Steppan C. M., Vorachek W. R., Wen P., Locker J.
RT A novel nk-2-related transcription factor associated with human fetal liver and hepatocellular carcinoma
RL J. Biol. Chem. 273:2917-2925 (1998).
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