AC T04461
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ID T04461
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DT 07.05.2001 (created); rio.
DT 21.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA POU4F3
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SY Brain-specific homeobox/POU domain protein 3C; Brn-3c; Brn3c.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002467 POU4F3; HGNC: POU4F3.
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HO unc-86 T01882 (C. elegans).
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CL C0007; POU; 3.1.10.4.3.
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SF POU-IV box similar to a highly conserved domain found in the N-terminus of all c-myc (e.g. T00140 T00143) family members [2];
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CP (fetus:) cochlea [1].
CN (adult:) brain, heart, placenta, skeletal muscle, lung, liver, kidney, pancreas lymphoblast tissues [1].
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FF mutations cause progressive hearing loss in adult humans [1];
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MX M01408 V$BRN3C_01.
MX M04087 V$POU4F3_02.
MX M07061 V$POU4F3_Q5.
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DR TRANSPATH: MO000028311.
DR PATHODB: MT010908.
DR UniProtKB: Q15319;
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RN [1]; RE0016112.
RX PUBMED: 9506947.
RA Vahava O., Morell R., Lynch E. D., Weiss S., Kagan M. E., Ahituv N., Morrow J. E., Lee M. K., Skvorak A. B., Morton C. C., Blumenfeld A., Frydman M., Friedman T. B., King M. C., Avraham K. B.
RT Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans
RL Science 279:1950-1954 (1998).
RN [2]; RE0016113.
RX PUBMED: 8248179.
RA Gerrero M. R., McEvilly R. J., Turner E., Lin C. R., O'Connell S., Jenne K. J., Hobbs M. V., Rosenfeld M. G.
RT Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.
RL Proc. Natl. Acad. Sci. USA 90:10841-10845 (1993).
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