AC T05017
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ID T05017
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DT 13.02.2002 (created); mas.
DT 12.11.2014 (updated); hna.
CO Copyright (C), QIAGEN.
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FA HNF-4
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SY AF-1; HNF4.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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CL C0002; CC (rec).
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SF two isoforms (at least for human and mouse) encoded by two different genes are known: HNF-4alpha and HNF-4gamma;
SF for HNF-4 alpha T05288 two splice variants are known: HNF-4alpha1 T00372, HNF-4alpha2 T02422.;
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CP (rat liver nuclear extracts).
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FF activator;
FF activates genes in liver, kidney, intestine;
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IN T08300 ER-alpha-L; human, Homo sapiens.
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MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M00764 V$HNF4DR1_Q3.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R00114.
BS R15923.
BS R15845.
BS R22701.
BS R27847.
BS R16063.
BS R16067.
BS R01612.
BS R20717.
BS R02657.
BS R16069.
BS R15905.
BS R15898.
BS R15920.
BS R16051.
BS R04478.
BS R14385.
BS R15902.
BS R15904.
BS R15927.
BS R19280.
BS R15791.
BS R15846.
BS R13273.
BS R18860.
BS R22492.
BS R22494.
BS R22487.
BS R22489.
BS R28575.
BS R13070.
BS R13018.
BS R13065.
BS R01690.
BS R12074.
BS R13032.
BS R20539.
BS R39333.
BS R64853.
BS R04031.
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DR TRANSPATH: MO000028775.
DR TRANSCOMPEL: C00582.
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RN [1]; RE0000898.
RX PUBMED: 2777781.
RA Leff T., Reue K., Melian A., Culver H., Breslow J. L.
RT A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types
RL J. Biol. Chem. 264:16132-16137 (1989).
RN [2]; RE0001369.
RX PUBMED: 2325658.
RA Trus M., Benvenisty N., Cohen H., Reshef L.
RT Developmentally Regulated Interaction of Liver Nuclear Factors with the Rat Phosphoenolpyruvate Carboxykinase Promoter
RL Mol. Cell. Biol. 10:2418-2422 (1990).
RN [3]; RE0002747.
RX PUBMED: 2161847.
RA Metzger S., Leff T., Breslow J. L.
RT Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells
RL J. Biol. Chem. 265:9978-9983 (1990).
RN [4]; RE0010737.
RX PUBMED: 7831301.
RA Hall R. K., Sladek F. M., Granner D. K.
RT The ophan receptors COUP-TF and HNF-4 serve a accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids
RL Proc. Natl. Acad. Sci. USA 92:412-416 (1995).
RN [5]; RE0047600.
RX PUBMED: 9717844.
RA Lee S. K., Choi H. S., Song M. R., Lee M. O., Lee J. W.
RT Estrogen receptor, a common interaction partner for a subset of nuclear receptors.
RL Mol. Endocrinol. 12:1184-1192 (1998).
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