AC T08915
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ID T08915
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DT 12.05.2006 (created); kar.
DT 06.12.2010 (updated); pum.
CO Copyright (C), QIAGEN.
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FA Smad5
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SY Smad-5.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002405 Smad5.
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CL C0041; SMAD.
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SZ 465 AA; 52.2 kDa (cDNA) (calc.).
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SQ MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
SQ QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
SQ VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
SQ NNAPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMAPDNSQP
SQ MDTSSNMIPQTMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
SQ DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
SQ NFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGW
SQ GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
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SC translated from EMBL #AF063006
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FT 1 132 
MH1 domain [1].
FT 13 137 
PS51075; MH1.
FT 26 135 
SM00523; dwAneu5.
FT 28 132 
PF03165; MH1 domain.
FT 133 263 
Linker region [1].
FT 264 461 
MH2 domain [1].
FT 265 443 
PF03166; MH2 domain.
FT 269 441 
SM00524; DWB.
FT 271 465 
PS51076; MH2.
FT 462 465 
SSXS motif [1].
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IN T09289 HOXA13; mouse, Mus musculus.
IN T09291 HOXD13; mouse, Mus musculus.
IN T11119 SIP1; mouse, Mus musculus.
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DR TRANSPATH: MO000081400.
DR EMBL: AF063006; AF063006.
DR EMBL: U77638; MMU77638.
DR UniProtKB: P97454; P70341.
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RN [1]; RE0015120.
RX PUBMED: 9076683.
RA Meersseman G., Verschueren K., Nelles L., Blumenstock C., Kraft H., Wuytens G., Remacle J., Kozak C.A., Tylzanowski P., Niehrs C., Huylebroeck D.
RT The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
RL Mech. Dev. 61:127-140 (1997).
RN [2]; RE0015603.
RA Chang H., Kraft H., Verschueren K., Wang P., Huylebroeck D., Matzuk M. M.
RT Genomic organization and expression of mouse Smad5
RL direct submission (EMBL) : ().
RN [3]; RE0015671.
RX PUBMED: 10079220.
RA Yang X., Castilla L. H., Xu X., Li C., Gotay J., Weinstein M., Liu P. P., Deng C.-X.
RT Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
RL Development 126:1571-1580 (1999).
RN [4]; RE0017601.
RX PUBMED: 10400677.
RA Verschueren K., Remacle J. E., Collart C., Kraft H., Baker B. S., Tylzanowski P., Nelles L., Wuytens G., Su M. T., Bodmer R., Smith J. C., Huylebroeck D.
RT SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.
RL J. Biol. Chem. 274:20489-20498 (1999).
RN [5]; RE0018465.
RX PUBMED: 10504300.
RA Ebisawa T., Tada K., Kitajima I., Tojo K., Sampath T. K., Kawabata M., Miyazono K., Imamura T.
RT Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation
RL J. Cell Sci. 112:3519-3527 (1999).
RN [6]; RE0020663.
RX PUBMED: 10224135.
RA Ishisaki A., Yamato K., Hashimoto S., Nakao A., Tamaki K., Nonaka K., ten Dijke P., Sugino H., Nishihara T.
RT Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
RL J. Biol. Chem. 274:13637-13642 (1999).
RN [7]; RE0027996.
RX PUBMED: 11278410.
RA Sasaki A., Masuda Y., Ohta Y., Ikeda K., Watanabe K.
RT Filamin associates with Smads and regulates transforming growth factor-beta signaling.
RL J. Biol. Chem. 276:17871-7 (2001).
RN [8]; RE0048182.
RX PUBMED: 16087734.
RA Williams T. M., Williams M. E., Heaton J. H., Gelehrter T. D., Innis J. W.
RT Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability.
RL Nucleic Acids Res. 33:4475-4484 (2005).
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