AC T09163
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ID T09163
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DT 31.07.2006 (created); jul.
DT 22.09.2011 (updated); grs.
CO Copyright (C), QIAGEN.
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FA OCA-B
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SY B-cell Oct-binding protein 1; Bob1; OBF1; OCA-B; Oct coactivator from B cells; POU2AF1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003984 POU2AF1; HGNC: POU2AF1.
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SZ 256 AA; 27.4 kDa (cDNA) (calc.).
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SQ MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAAPAPTAVVLPHQPLATY
SQ TTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPWTPYTEYVPHEAVSCPYSA
SQ DMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPAVGPPLEGPEHQAPLTYFPWP
SQ QPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQDMEDPRRAASSLTIDKLLLEEE
SQ DSDAYALNHTLSVEGF
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SC Swiss-Prot#Q16633
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FT 1 65 
interaction domain [7].
FT 26 32 
important for interaction with POU domains [7].
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IN T00647 Oct-2; human, Homo sapiens.
IN T00545 POU2F1; human, Homo sapiens.
IN T08520 TBP-isoform1; human, Homo sapiens.
IN T08496 TFIIB; human, Homo sapiens.
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MX M02113 V$OCAB_Q6.
MX M00795 V$OCT_Q6.
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DR TRANSPATH: MO000083956.
DR EMBL: X83504;
DR EMBL: Z47550;
DR UniProtKB: Q16633;
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RN [1]; RE0000370.
RX PUBMED: 2328728.
RA Mueller-Immerglueck M. M., Schaffner W., Matthias P.
RT Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells
RL EMBO J. 9:1625-1634 (1990).
RN [2]; RE0004283.
RX PUBMED: 7779176.
RA Gstaiger M., Knoepfel L., Georgiev O., Schaffner W., Hovens C. M.
RT A B-cell coactivator of octamer-binding transcription factors
RL Nature 373:360-362 (1995).
RN [3]; RE0004399.
RX PUBMED: 1423591.
RA Luo Y., Fujii H., Gerster T., Roeder R. G.
RT A novel B cell-derived coactivator potentiates the activation of immunoglogulin promoters by octamer-binding transcription
RL Cell 71:231-241 (1992).
RN [4]; RE0004442.
RX PUBMED: 7859290.
RA Strubin M., Newell J. W., Matthias P.
RT OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
RL Cell 80:497-506 (1995).
RN [5]; RE0005623.
RX PUBMED: 8657574.
RA Schubart D. B., Sauter P., Massa S., Friedl E. M., Schwarzenbach H., Matthias P.
RT Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1
RL Nucleic Acids Res. 24:1913-1920 (1996).
RN [6]; RE0005624.
RX PUBMED: 7623806.
RA Luo Y., Roeder R. G.
RT Cloning, functional charcterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B
RL Mol. Cell. Biol. 15:4115-4124 (1995).
RN [7]; RE0005625.
RX PUBMED: 8654375.
RA Gstaiger M., Georgiev O., van Leeuwen H., an der Vliet P., Schaffner W.
RT The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation
RL EMBO J. 15:2781-2790 (1996).
RN [8]; RE0005626.
RX PUBMED: 8769650.
RA Cepek K. L., Chasman D. I., Sharp P. A.
RT Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B
RL Genes Dev. 10:2079-2088 (1996).
RN [9]; RE0047947.
RX PUBMED: 11134019.
RA Kakizawa T., Miyamoto T., Ichikawa K., Takeda T., Suzuki S., Mori J., Kumagai M., Yamashita K., Hashizume K.
RT Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor.
RL J. Biol. Chem. 276:9720-9725 (2001).
RN [10]; RE0066536.
RX PUBMED: 16186795.
RA Heckman C. A., Duan H., Garcia P. B., Boxer L. M.
RT Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.
RL Oncogene 25:888-898 (2006).
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