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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T09383 XX ID T09383 XX DT 06.10.2006 (created); apk. DT 19.02.2014 (updated); msr. CO Copyright (C), QIAGEN. XX FA GABP-alpha XX SY E4TF1-60; EF-1A alpha; GA binding protein alpha subunit; NRF-2alpha; nuclear respiratory factor 2alpha. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003950 GABPA; HGNC: GABPA. XX CL C0016; ETS. XX SZ 454 AA; 51.3 kDa (cDNA) (calc.), 56 kDa [2] XX SQ MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQ SQ CSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTV SQ EVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERL SQ GIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEIL SQ WSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAP SQ RISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKW SQ GQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE SQ CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN XX SC conceptually translated from EMBL/GenBank/DDBJ #D13318 XX FT 66 368 PF00478; IMP dehydrogenase / GMP reductase domain. FT 170 251 PF02198; Sterile alpha motif (SAM)/Pointed domain. FT 170 251 SM00251; SAM2_3. FT 293 407 DNA-binding domain [1]. FT 319 399 POINTED domain [6]. FT 319 402 PF00178; Ets-domain. FT 319 404 SM00413; etsneu2. FT 320 400 PS50061; ETS_DOMAIN_3. FT 322 390 PS50140; HSF_ETS. FT 407 454 interaction with GABP-beta1 (E4TF1-53) [1]. XX IN T08465 C/EBPalpha-isoform1; human, Homo sapiens. IN T06595 C/EBPbeta-FL; human, Homo sapiens. IN T08484 Sp1-isoform1; human, Homo sapiens. XX MX M08881 V$ETSLIKE_Q4. MX M00971 V$ETS_Q6. MX M02074 V$GABPA_02. MX M01660 V$GABPA_Q4. MX M00341 V$GABP_B. XX BS R26409. BS R26656. BS R20444. BS R21653. BS R14803. BS R13222. BS R20429. BS R20476. BS R20560. XX DR TRANSPATH: MO000088374. DR EMBL: D13318; DR UniProtKB: Q06546; XX RN [1]; RE0000561. RX PUBMED: 8137823. RA Sawada J.-I., Goto M., Sawa C., Watanabe H., Handa H. RT Transcriptional activation through the tetrameric complex formation of E4TF1 subunits RL EMBO J. 13:1396-1402 (1994). RN [2]; RE0000801. RX PUBMED: 8383622. RA Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C. RT Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an Ets domain activator of viral promoters RL Genes Dev. 7:380-392 (1993). RN [3]; RE0001746. RX PUBMED: 8441384. RA Watanabe H., Sawada J.-I., Yano K.-I., Yamaguchi K., Goto M., Handa H. RT cDNA cloning of transcription factor E4TF1 subunits with Ets and Notch motifs RL Mol. Cell. Biol. 13:1385-1391 (1993). RN [4]; RE0014101. RX PUBMED: 1336180. RA Bolwig G. M., Bruder J. T., Hearing P. RT Different binding site requirements for binding and activation for the bipartite enhancer factor EF-1A RL Nucleic Acids Res. 20:6555-6564 (1992). RN [5]; RE0048580. RX PUBMED: 15928042. RA Shimokawa T., Ra C. RT C/EBPalpha functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (Fc alphaR, CD89) gene promoter. RL Blood 106:2534-2542 (2005). RN [6]; RE0022459. RX PUBMED: 10644770. RA Kas K., Finger E., Grall F., Gu X., Akbarali Y., Boltax J., Weiss A., Oettgen P., Kapeller R., Libermann T. A. RT ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. RL J. Biol. Chem. 275:2986-2998 (2000). XX //