AC T09383
XX
ID T09383
XX
DT 06.10.2006 (created); apk.
DT 19.02.2014 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA GABP-alpha
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SY E4TF1-60; EF-1A alpha; GA binding protein alpha subunit; NRF-2alpha; nuclear respiratory factor 2alpha.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003950 GABPA; HGNC: GABPA.
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CL C0016; ETS.
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SZ 454 AA; 51.3 kDa (cDNA) (calc.), 56 kDa [2]
XX
SQ MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQ
SQ CSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTV
SQ EVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERL
SQ GIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEIL
SQ WSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAP
SQ RISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKW
SQ GQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE
SQ CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN
XX
SC conceptually translated from EMBL/GenBank/DDBJ #D13318
XX
FT 66 368 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 170 251 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 170 251 
SM00251; SAM2_3.
FT 293 407 
DNA-binding domain [1].
FT 319 399 
POINTED domain [6].
FT 319 402 
PF00178; Ets-domain.
FT 319 404 
SM00413; etsneu2.
FT 320 400 
PS50061; ETS_DOMAIN_3.
FT 322 390 
PS50140; HSF_ETS.
FT 407 454 
interaction with GABP-beta1 (E4TF1-53) [1].
XX
IN T08465 C/EBPalpha-isoform1; human, Homo sapiens.
IN T06595 C/EBPbeta-FL; human, Homo sapiens.
IN T08484 Sp1-isoform1; human, Homo sapiens.
XX
MX M08881 V$ETSLIKE_Q4.
MX M00971 V$ETS_Q6.
MX M02074 V$GABPA_02.
MX M01660 V$GABPA_Q4.
MX M00341 V$GABP_B.
XX
BS R26409.
BS R26656.
BS R20444.
BS R21653.
BS R14803.
BS R13222.
BS R20429.
BS R20476.
BS R20560.
XX
DR TRANSPATH: MO000088374.
DR EMBL: D13318;
DR UniProtKB: Q06546;
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RN [1]; RE0000561.
RX PUBMED: 8137823.
RA Sawada J.-I., Goto M., Sawa C., Watanabe H., Handa H.
RT Transcriptional activation through the tetrameric complex formation of E4TF1 subunits
RL EMBO J. 13:1396-1402 (1994).
RN [2]; RE0000801.
RX PUBMED: 8383622.
RA Virbasius J. V., Virbasius C.-M. A., Scarpulla R. C.
RT Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an Ets domain activator of viral promoters
RL Genes Dev. 7:380-392 (1993).
RN [3]; RE0001746.
RX PUBMED: 8441384.
RA Watanabe H., Sawada J.-I., Yano K.-I., Yamaguchi K., Goto M., Handa H.
RT cDNA cloning of transcription factor E4TF1 subunits with Ets and Notch motifs
RL Mol. Cell. Biol. 13:1385-1391 (1993).
RN [4]; RE0014101.
RX PUBMED: 1336180.
RA Bolwig G. M., Bruder J. T., Hearing P.
RT Different binding site requirements for binding and activation for the bipartite enhancer factor EF-1A
RL Nucleic Acids Res. 20:6555-6564 (1992).
RN [5]; RE0048580.
RX PUBMED: 15928042.
RA Shimokawa T., Ra C.
RT C/EBPalpha functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (Fc alphaR, CD89) gene promoter.
RL Blood 106:2534-2542 (2005).
RN [6]; RE0022459.
RX PUBMED: 10644770.
RA Kas K., Finger E., Grall F., Gu X., Akbarali Y., Boltax J., Weiss A., Oettgen P., Kapeller R., Libermann T. A.
RT ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.
RL J. Biol. Chem. 275:2986-2998 (2000).
XX
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