AC T00165
XX
ID T00165
XX
DT 01.06.1993 (created); ewi.
DT 03.03.2005 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA deltaCREB
XX
SY CREB-327; CREB-A; deltaCREB.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009126 Creb1.
XX
CL C0008; bZIP; 1.1.7.1.1.2.
XX
SZ 327 AA; 35.1 kDa (cDNA) (calc.).
XX
SQ MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
SQ GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY
SQ RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA
SQ NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI
SQ RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR
SQ VAVLENQNKTLIEELKALKDLYCHKSD
XX
SC edited Swiss-Prot #P15337
XX
FT 23 324 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 87 146 
PS50953; KID.
FT 99 139 
PF02173; pKID domain.
FT 267 325 
SM00338; brlzneu.
FT 267 327 
PF00170; bZIP transcription factor.
FT 269 320 
PS50217; BZIP.
XX
SF K289 and K291: important for DNA-binding [3];
XX
CP ubiquitous (placenta).
XX
FF splice variant from CREB (AA 88-101 of CREB missing);
FF only 10% trans-activation capability compared to CREB;
FF transcription is induced by glucocorticoids (glioma cells) [6];
XX
IN T00163 CREB-A; human, Homo sapiens.
IN T00164 CREB1; rat, Rattus norvegicus.
IN T01385 CREB1; cattle, Bos taurus.
IN T00989 CREB; mouse, Mus musculus.
IN T01127 CREB; pig, Sus scrofa.
IN T01307 CREB; hamster, Cricetulus sp.
IN T01380 CREB; mink, Mustela vison.
IN T00165 deltaCREB; rat, Rattus norvegicus.
XX
MX M07248 V$CREB1_Q3.
MX M03544 V$CREB1_Q6.
MX M00981 V$CREBATF_Q6.
MX M00039 V$CREB_01.
MX M00113 V$CREB_02.
MX M00177 V$CREB_Q2.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00178 V$CREB_Q4.
MX M00917 V$CREB_Q4_01.
MX M00114 V$TAXCREB_01.
MX M00115 V$TAXCREB_02.
XX
BS R04110.
BS R04577.
BS R00963.
BS R01358.
BS R04578.
BS R04579.
XX
DR TRANSPATH: MO000031257.
DR EMBL: X14788;
DR UniProtKB: P15337-2;
XX
RN [1]; RE0000233.
RX PUBMED: 2137373.
RA Yamamoto K. K., Gonzalez G. A., Menzel P., Rivier J., Montminy M. R.
RT Characterization of a bipartite activator domain in transcription factor CREB
RL Cell 60:611-617 (1990).
RN [2]; RE0001080.
RX PUBMED: 8394325.
RA Quinn P. G.
RT Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription
RL J. Biol. Chem. 268:16999-17009 (1993).
RN [3]; RE0001104.
RX PUBMED: 1834659.
RA Andrisani O. M., Dixon J. E.
RT Involvement of lysine residues 289 and 291 of the cAMP-responsive element-binding protein in the recognition of the cAMP-responsive element
RL J. Biol. Chem. 266:21444-21450 (1991).
RN [4]; RE0001639.
RX PUBMED: 2141384.
RA Quinn P. G., Granner D. K.
RT Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element
RL Mol. Cell. Biol. 10:3357-3364 (1990).
RN [5]; RE0002506.
RX PUBMED: 2142528.
RA Berkowitz L. A., Gilman M. Z.
RT Two distinct forms of active transcription factor CREB (cAMP response element binding protein)
RL Proc. Natl. Acad. Sci. USA 87:5258-5262 (1990).
RN [6]; RE0002833.
RX PUBMED: 1531873.
RA Jungmann R. A.
RT Glucocorticoid induction
RL Nucleic Acids Res. 20:825-829 (1992).
XX
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