AC T01881
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ID T01881
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DT 08.08.1996 (created); ewi.
DT 19.02.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Brn-3b
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SY Brn-3.2; Brn-3b; Brn3.2; Brn3b; POU4F2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002465 Pou4f2.
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HO unc-86 T01882 (C. elegans).
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CL C0007; POU; 3.1.10.4.2.
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SF Brn-3b -/- mice show a loss of 60-70% of retinal ganglion cells, altered POU4F1 T01877 T01878 expression and disorganized morphology of the superior colliculus [6];
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CP embryonic brain [5]; (E13.5-P8:) retinal ganglion cells [6] [6] [5].
CN mature sensory neurons [5].
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FF repressor, due to differences in the POU domain when compared with the activator POU4F1 T01877 T01878 [1];
FF the N-terminal region acts as antagonist of the transforming activity of POU4F1(l) T01877 [3];
FF declining levels upon neuronal development, completely absent from mature sensory neurons [5];
FF reduced levels upon enhanced cAMP concentration and serum deprivation [4];
FF Brn-3b and POU4F3 T04462 critically affect terminal differentiation events in specific sensorineural cells, consistent with the paralogous factor unc-86 T01882 in C. elegans [6];
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MX M05385 V$BRN3B_02.
MX M07036 V$BRN3B_Q2.
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DR TRANSPATH: MO000026001.
DR UniProtKB: Q63934;
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RN [1]; RE0004225.
RX PUBMED: 7935408.
RA Morris P. J., Theil T., Ring C. J. A., Lillycrop K. A., Moroy T., Latchman D. S.
RT The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in POU domain
RL Mol. Cell. Biol. 14:6907-6914 (1994).
RN [2]; RE0004227.
RX PUBMED: 8162704.
RA Theil T., Zechner U., Klett C., Adolph S., Moroy T.
RT Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes
RL Cytogenet. Cell Genet. 66:267-271 (1994).
RN [3]; RE0004385.
RX PUBMED: 8290353.
RA Theil T., McLean-Hunter S., Zoernig M., Moeroey T.
RT Mouse BRN-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of BRN-3A
RL Nucleic Acids Res. 21:5921-5929 (1993).
RN [4]; RE0004413.
RX PUBMED: 8065921.
RA Budhram-Mahadeo V., Theil T., Morris P. J., Lillycrop K. A., Moroy T., Latchman D. S.
RT The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells
RL Nucleic Acids Res. 22:3092-3098 (1994).
RN [5]; RE0004440.
RX PUBMED: 1383937.
RA Lillycrop K. A., Budrahan V. S., Lakin N. D., Terrenghi G., Wood J. N., Polak J. M., Latchman D. S.
RT A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells
RL Nucleic Acids Res. 20:5093-5096 (1992).
RN [6]; RE0016131.
RX PUBMED: 8637595.
RA Erkman L., McEvilly R. J., Luo L., Ryan A. K., Hooshmand F., O'Connell S. M., Keithley E. M., Rapaport D. H., Ryan A. F., Rosenfeld M. G.
RT Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
RL Nature 381:603-606 (1996).
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