AC T04462
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ID T04462
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DT 07.05.2001 (created); rio.
DT 07.11.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA POU4F3
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SY Brn-3.1; Brn-3c; Brn3c.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002468 Pou4f3.
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HO unc-86 T01882 (C. elegans).
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CL C0007; POU; 3.1.10.4.3.
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SF POU-IV box similar to a highly conserved domain found in the N-terminus of all c-myc (e.g. T00140 T00143) family members [1];
SF POU4F3 -/- mice show deficits in balance and coordination, marked hyperactivity and complete deafness (due to defects in the organ of Corti, spiral, vestibular ganglia and hair-cell differentiation) [2];
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CP (E13:) weakly in sensory ganglia and dorsal horn [1].
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FF POU4F3 and POU4F2 T01881 critically affect terminal differentiation events in specific sensorineural cells, consistent with the paralogous factor unc-86 T01882 in C. elegans [2];
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MX M01408 V$BRN3C_01.
MX M07061 V$POU4F3_Q5.
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BS R38182.
BS R38183.
BS R38185.
BS R38186.
BS R38187.
BS R64770.
BS R64773.
BS R28517.
BS R28515.
BS R28516.
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DR TRANSPATH: MO000028312.
DR UniProtKB: Q63955;
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RN [1]; RE0016113.
RX PUBMED: 8248179.
RA Gerrero M. R., McEvilly R. J., Turner E., Lin C. R., O'Connell S., Jenne K. J., Hobbs M. V., Rosenfeld M. G.
RT Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.
RL Proc. Natl. Acad. Sci. USA 90:10841-10845 (1993).
RN [2]; RE0016131.
RX PUBMED: 8637595.
RA Erkman L., McEvilly R. J., Luo L., Ryan A. K., Hooshmand F., O'Connell S. M., Keithley E. M., Rapaport D. H., Ryan A. F., Rosenfeld M. G.
RT Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
RL Nature 381:603-606 (1996).
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