AC T05669
AS T13733, T15509.
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ID T05669
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DT 29.08.2003 (created); oke.
DT 14.12.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA c-Jun:c-Fos
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SY AP-1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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CL C0008; bZIP.
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SF heterodimer, for individual polypeptides see rat c-Jun T00132 and rat c-Fos T00124;
SF often is referred to as AP-1 T00031;
SF leucine zippers of both c-Jun and c-Fos are involved in direct interactions with PEBPalphaA T01063 [4];
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FF activator;
FF mediates gene induction by a variety of extra cellular signals;
FF mediates PTH- (parathyroid hormone) dependent gene induction in bone cells [4];
FF mediates gene induction in response to IL-1beta in smooth muscle cells [5];
FF functionally cooperates and physically interacts with the mouse PEBPalphaA T01063 [4];
FF functionally cooperates with an architectural factor HMG-I(Y) [5];
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IN T10523 c-Ets-2; human, Homo sapiens.
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MX M00925 V$AP1_Q6_01.
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BS R20747.
BS R20934.
BS R22690.
BS R24899.
BS R04957.
BS R05082.
BS R05089.
BS R05091.
BS R04127.
BS R00235.
BS R01036.
BS R14766.
BS R04064.
BS R14160.
BS R26227.
BS R31275.
BS R18402.
BS R25828.
BS R23475.
BS R23476.
BS R23477.
BS R32598.
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DR TRANSPATH: MO000037369.
DR TRANSCOMPEL: C00083.
DR TRANSCOMPEL: C00141.
DR TRANSCOMPEL: C00142.
DR TRANSCOMPEL: C00143.
DR TRANSCOMPEL: C00147.
DR TRANSCOMPEL: C00156.
DR TRANSCOMPEL: C00164.
DR TRANSCOMPEL: C00232.
DR TRANSCOMPEL: C00397.
DR TRANSCOMPEL: C00419.
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RN [1]; RE0004648.
RX PUBMED: 1406655.
RA Hsu J. C., Bravo R., Taub R.
RT Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration
RL Mol. Cell. Biol. 12:4654-4665 (1991).
RN [2]; RE0004656.
RX PUBMED: 2118682.
RA Abate C., Patel L., Rauscher III F. J., Curran T.
RT Redox regulation of Fos and Jun DNA-binding activity in vitro
RL Science 249:1157-1161 (1990).
RN [3]; RE0016714.
RX PUBMED: 9334186.
RA Basuyaux J. P., Ferreira E., Stehelin D., Buttice G.
RT The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.
RL J. Biol. Chem. 272:26188-26195 (1997).
RN [4]; RE0023220.
RX PUBMED: 11274169.
RA Hess J., Porte D., Munz C., Angel P.
RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
RL J. Biol. Chem. 276:20029-20038 (2001).
RN [5]; RE0024052.
RX PUBMED: 10657993.
RA Foster L. C., Wiesel P., Huggins G. S., Panares R., Chin M. T., Pellacani A., Perrella M. A.
RT Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells.
RL FASEB J. 14:368-378 (2000).
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