AC T00003
XX
ID T00003
XX
DT 20.10.1992 (created); ewi.
CO Copyright (C), QIAGEN.
XX
FA AS-C T3
XX
SY Achaete-Scute T3; AS-C T3; L'Sc; L'Sc; Lethal of Scute.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
CL C0010; bHLH.
XX
SZ 257 AA; 29.0 kDa (gene) (calc.).
XX
SQ MTSICSSKFQQQHYQLTNSNIFLLQHQHHHQTQQHQLIAPKIPLGTSQLQNMQQSQQSNV
SQ GPMLSSQKKKFNYNNMPYGEQLPSVARRNARERNRVKQVNNGFVNLRQHLPQTVVNSLSN
SQ GGRGSSKKLSKVDTLRIAVEYIRGLQDMLDDGTASSTRHIYNSADESSNDGSSYNDYNDS
SQ LDSSQQFLTGATQSAQSHSYHSASPTPSYSGSEISGGGYIKQELQEQDLKFDSFDSFSDE
SQ QPDDEELLDYISSWQEQ
XX
SC Swiss-Prot#P09774
XX
FT 84 146 
PS50888; HLH.
FT 86 146 
PF00010; Helix-loop-helix DNA-binding domain.
FT 89 151 
SM00353; finulus.
XX
SF heterodimerization required for efficient DNA-binding [4];
XX
CP neuroectoderm [5].
CN neurons [5].
XX
FF activator, involved in neurogenesis, presumably by controlling the segregation of different neural lineages from epidermal precursors [5] [7];
FF promotes development of sensory organ mother cells independently from the other AS-C genes [6];
FF mRNA accumulates at blastoderm stage;
FF antagonized by emc [2];
XX
IN T01034 Da; fruit fly, Drosophila melanogaster.
IN T00204 E12; human, Homo sapiens.
IN T00675 E12; rat, Rattus norvegicus.
IN T01787 E12; clawed frog, Xenopus laevis.
IN T00207 E47; human, Homo sapiens.
IN T00674 E47; rat, Rattus norvegicus.
IN T01788 E47; mouse, Mus musculus.
XX
BS R03719.
BS R03718.
BS R00883.
BS R00884.
BS R00885.
XX
DR TRANSPATH: MO000024633.
DR EMBL: X12549;
DR UniProtKB: P09774;
DR FLYBASE: FBgn0002561; l(1)sc.
XX
RN [1]; RE0000053.
RX PUBMED: 2503252.
RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. Y., Jan Y. N., Cabrera C. V., Buskin J. N., Hauschka S. D., Lassar A. B., Weintraub H., Baltimore D.
RT Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
RL Cell 58:537-544 (1989).
RN [2]; RE0000189.
RX PUBMED: 1690605.
RA Garrell J., Modolell J.
RT The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein
RL Cell 61:39-48 (1990).
RN [3]; RE0000471.
RX PUBMED: 2461300.
RA Alonso L. G., Cabrera C. V.
RT The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes
RL EMBO J. 7:2585-2591 (1988).
RN [4]; RE0000540.
RX PUBMED: 1915272.
RA Cabrera C. V., Alonso M. C.
RT Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila
RL EMBO J. 10:2965-2973 (1991).
RN [5]; RE0003612.
RX PUBMED: 3607875.
RA Cabrera C. V., Martinez-Arias A., Bate M.
RT The expression of three members of the achaete-scute gene complex correlates with neuroblast segregation in Drosophila
RL Cell 50:425-433 (1987).
RN [6]; RE0003613.
RX PUBMED: 17248895.
RA Garcia-Bellido A.
RT Genetic analysis of the achaete-scute system of Drosophila melanogaster
RL Genetics 91:491-520 (1979).
RN [7]; RE0003614.
RX PUBMED: 8287481.
RA Hinz U., Giebel B., Campos-Ortega J. A.
RT The basic helix-loop-helix domain of Drosophila Lethal of Scute protein is sufficient for proneural function and activates neurogenic genes
RL Cell 76:77-87 (1994).
XX
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