AC T01034
XX
ID T01034
XX
DT 20.02.1994 (created); ewi.
DT 21.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Da
XX
SY da; Daughterless.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G090465 da.
XX
CL C0010; bHLH.
XX
SZ 710 AA; 73.9 kDa (cDNA) (calc.).
XX
SQ MATSDDEPMHLYEVFQNCFNKIANKQPTGTVGADRGGGGGYHSPYGSLGVENGMYPSDFN
SQ SMHDTVNGGNNRYANASTVDQYFDSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSGH
SQ SIDQQQQQVHQADGLGMGGGGGGGVGADGMHCPVTTGLPPISSFRPTSGGIGGPGAGQQA
SQ PVNVNVNPPAVFNSPQAHNHNHTVQAQHSALSTAGPLGHHSLNHTPHAHSHTLPLPHALP
SQ HGHTLPHPHHSQQNSPAVQSSDAFSGAGASVKVAGAGNSSAAALRQQMYMPADQSISSFG
SQ SNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGGPSSSYASEMVPVSSLHTMAS
SQ VFQGVRMEERLDDALNVLRNHCEPEMLAGVNQSLASIDNIDALTSFVPNSPSHLGSGGNS
SQ GSVSNTSNAALVHEVLALGAAAAAGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEH
SQ TAISNSVPAGVSTTSSLTSLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADED
SQ DDAEPAVKAIREKERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMA
SQ VEVIMTLEQQVRERNLNPKAACLKRREEEKAEDGPKLSAQHHMIPQPQQVGGTPGSSYHS
SQ QPAQLVPPSSQTISTMTISLPVNQANNGLPPHLQQQQQQQSQLGHAQLPQ
XX
SC Swiss-Prot#P11420
XX
FT 74 523 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 553 608 
PS50888; HLH.
FT 555 608 
PF00010; Helix-loop-helix DNA-binding domain.
FT 560 613 
SM00353; finulus.
XX
SF a similar putative loop-helix motif as in E2A and E2-2 gene products and HEB was recognized in Da by homology [4];
SF weak biding by Da-homodimers, high-affinity binding by heterodimers with AS-C proteins [3];
XX
CP widespread expression.
CN maternal germline (oocyte until stage 10, unfertilized eggs) [10].
XX
FF activator [3];
FF involved in the formation of the central and peripheral nervous system;
FF also acts as a numerator in the sex-determining X:A ratio [9];
FF antagonized by Emc [7];
XX
IN T00005 Ac; fruit fly, Drosophila melanogaster.
IN T00003 AS-C T3; fruit fly, Drosophila melanogaster.
IN T01628 Ato; fruit fly, Drosophila melanogaster.
IN T01569 EHAND; mouse, Mus musculus.
IN T00004 Sc; fruit fly, Drosophila melanogaster.
XX
BS R03719.
BS R03718.
BS R00885.
XX
DR TRANSPATH: MO000025357.
DR EMBL: J03148;
DR EMBL: Y00221;
DR UniProtKB: P11420;
DR FLYBASE: FBgn0000413; da.
XX
RN [1]; RE0000053.
RX PUBMED: 2503252.
RA Murre C., McCaw P. S., Vaessin H., Caudy M., Jan L. Y., Jan Y. N., Cabrera C. V., Buskin J. N., Hauschka S. D., Lassar A. B., Weintraub H., Baltimore D.
RT Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
RL Cell 58:537-544 (1989).
RN [2]; RE0000092.
RX PUBMED: 2493990.
RA Murre C., McCaw P. S., Baltimore D.
RT A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
RL Cell 56:777-783 (1989).
RN [3]; RE0000540.
RX PUBMED: 1915272.
RA Cabrera C. V., Alonso M. C.
RT Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila
RL EMBO J. 10:2965-2973 (1991).
RN [4]; RE0003543.
RX PUBMED: 8423802.
RA Quong M. W., Massari M. E., Zwart R., Murre C.
RT A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
RL Mol. Cell. Biol. 13:792-800 (1993).
RN [5]; RE0003620.
RX PUBMED: 7958878.
RA Singson A., Leviten M. W., Bang A. G., Hua X. H., Posakony J. W.
RT Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling
RL Genes Dev. 8:2058-2071 (1994).
RN [6]; RE0003637.
RX PUBMED: 8324823.
RA Jarman A. P., Grau Y., Jan L. Y., Jan Y. N.
RT atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system
RL Cell 73:1307-1321 (1993).
RN [7]; RE0003693.
RX PUBMED: 1764999.
RA van Doren M., Ellis H. M., Posakony J. W.
RT The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
RL Development 113:245-255 (1991).
RN [8]; RE0003752.
RX PUBMED: 3203380.
RA Caudy M., Vaessin H., Brand M., Tuma R., Jan L. Y., Jan Y. N.
RT Daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.
RL Cell 55:1061-1067 (1988).
RN [9]; RE0003753.
RX PUBMED: 2850968.
RA Cronmiller C., Schedl P., Cline T. W.
RT Molecular characterisation of daughterless, a Drosophila sex determination gene with multiple roles in development
RL Genes Dev. 2:1666-1676 (1988).
RN [10]; RE0003754.
RX PUBMED: 8217842.
RA Cronmiller C., Cummings C. A.
RT The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development
RL Mech. Dev. 42:159-169 (1993).
XX
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