AC T01314
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ID T01314
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DT 23.10.1994 (created); ewi.
DT 16.07.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA CREMalpha
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SY cAMP responsive element modulator; CREM; CREM-alpha.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000532 Crem.
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CL C0008; bZIP.
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SZ 245 AA; 27.5 kDa (cDNA) (calc.).
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SQ MSKCGRKKYMRTNVRQMTMETVESQQDRSVTRSVAEHSSAHMQTGQISVPTLAQVATIAE
SQ TDDSADSEVIDSHKRREILSRRPSYRKILNELSSDVPGIPKIEEEKSEEEGTPPNIATMA
SQ VPTSIYQTSTGQYNEETDLAPSHMAAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQ
SQ QLAEEATRKRELRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLY
SQ CHKAE
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SC Swiss-Prot#P27699-2
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FT 36 95 
PS50953; KID.
FT 48 88 
PF02173; pKID domain.
FT 117 176 
kinase-inducible modulating domain (KID) [3].
FT 169 227 
SM00338; brlzneu.
FT 169 229 
PF00170; bZIP transcription factor.
FT 171 222 
PS50217; BZIP.
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SF encoded by crem exons 1 (B), 3 (E), 4 (F), 6 (X), 7 (H), and the 5'-half of exon 8 (Ia) [9];
SF several alternative splice variants including some with an alternative DNA-binding domain [1];
SF very similar if not identical DNA-binding specificity as CREB [1];
SF homo- and heterodimeric DNA-binding with CREB [1];
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CP mRNA: adult brain: inner layer of cerebral cortex, anterior thalamus, hippocampus, hypothalamus [8], pituitary gland; kidney, heart; very low levels in testis [2] [2] [8].
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FF repressor, CREB antagonist as dominant negative regulator [1] [6];
FF may confer cAMP/PKA-dependent effects, even stimulatory ones, onto other factors bound in the vicinity of CREMalpha [3];
FF CREMalpha is upregulated in CREB -/- mice;
FF use of an alternative polyadenylation site in the testis of FSH-treated rodents leads to a transcript with enhanced stability [7];
FF osmotic stimulation of the supraoptic nucleus, induction of CREMalpha (and -beta) correlates with down-regulation of c-fos [8];
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IN T00163 CREB-A; human, Homo sapiens.
IN T00164 CREB1; rat, Rattus norvegicus.
IN T01385 CREB1; cattle, Bos taurus.
IN T00989 CREB; mouse, Mus musculus.
IN T01127 CREB; pig, Sus scrofa.
IN T01307 CREB; hamster, Cricetulus sp.
IN T01380 CREB; mink, Mustela vison.
IN T01314 CREMalpha; mouse, Mus musculus.
IN T01319 ICER; rat, Rattus norvegicus.
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MX M00981 V$CREBATF_Q6.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00917 V$CREB_Q4_01.
MX M01820 V$CREM_Q6.
MX M08803 V$CREM_Q6_01.
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BS R15129.
BS R14617.
BS R01358.
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DR TRANSPATH: MO000025575.
DR EMBL: M60285;
DR UniProtKB: P27699-2;
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RN [1]; RE0000262.
RX PUBMED: 1847666.
RA Foulkes N. S., Borrelli E., Sassone-Corsi P.
RT CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
RL Cell 64:739-749 (1991).
RN [2]; RE0001912.
RX PUBMED: 1370576.
RA Foulkes N. S., Mellstroem B., Benusiglio E., Sassone-Corsi P.
RT Developmental switch of CREM function during spermatogenesis: from antagonist to activator
RL Nature 355:80-84 (1992).
RN [3]; RE0001913.
RX PUBMED: 8102791.
RA Brindle P., Linke S., Montminy M.
RT Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors
RL Nature 364:821-824 (1993).
RN [4]; RE0001915.
RX PUBMED: 8397338.
RA Stehle J. H., Foulkes N. S., Molina C. A., Simonneaux V., Pevet P., Sassone-Corsi P.
RT Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland
RL Nature 365:314-320 (1993).
RN [5]; RE0002563.
RX PUBMED: 8202542.
RA Hummler E., Cole T. J., Blendy J. A., Ganss R., Aguzzi A., Schmid W., Beermann F., Schuetz G.
RT Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors
RL Proc. Natl. Acad. Sci. USA 91:5647-5651 (1994).
RN [6]; RE0003158.
RX PUBMED: 8458330.
RA Laoide B.M., Foulkes N.S., Schlotter F., Sassone-Corsi P.
RT The functional versatility of CREM is determined by its modular structure
RL EMBO J. 12:1179-1191 (1993).
RN [7]; RE0005265.
RX PUBMED: 7681549.
RA Foulkes N. S., Schlotter F., Pevet P., Sassone-Corsi P.
RT Pituitary hormone FSH directs the CREM functional switch during spermatogenesis
RL Nature 362:264-267 (1993).
RN [8]; RE0005266.
RX PUBMED: 8386526.
RA Mellstroem B., Naranjo J. R., Foulkes N. S., Lafarga M., Sassone-Corsi P.
RT Transcriptional response to cAMP in brain: specific distribution and induction of CREM antagonists
RL Neuron 10:655-665 (1993).
RN [9]; RE0000312.
RX PUBMED: 3023048.
RA Moncollin V., Miyamoto N. G., Zheng X. M., Egly J. M.
RT Identification of a factor specific for the upstream element of the adenovirus-2 major late promoter
RL EMBO J. 5:2577-2584 (1986).
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