AC T01384
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ID T01384
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DT 06.12.1994 (created); ewi.
DT 13.05.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA pX
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SY HBx; protein X.
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OS HBV, human hepatitis B virus
OC viridae; ds-DNA enveloped viruses; hepadnaviridae
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SZ 154 AA; 16.5 kDa (calc.).
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SQ MAARLYCQLDPSRDVLCLRPVGAESRGRPLSGPLGTLSSPSPSAVPADHGAHLSLRGLPV
SQ CAFSSAGPCALRFTSARCMATTVNAHQILPKVLHKRTLGLPAMSTTDLEAYFKDCVFKDW
SQ EELGEEIRLMIFVLGGCRHKLVCAPAPCNFFTSA
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SC translated from EMBL #Z35717
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FT 1 142 
PF00739; Trans-activation protein X.
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SF various viral subtypes;
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FF Without binding to DNA by itself, pX enters a DNA-binding complex with CREB or CRE-BP1 thereby directing them to a CRE-like sequence within the HBV enhancer [1];
FF p53-independent repression of p21 promoter via an Sp1-site [2] [3];
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IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T00163 CREB-A; human, Homo sapiens.
IN T00164 CREB1; rat, Rattus norvegicus.
IN T01385 CREB1; cattle, Bos taurus.
IN T00989 CREB; mouse, Mus musculus.
IN T01127 CREB; pig, Sus scrofa.
IN T01307 CREB; hamster, Cricetulus sp.
IN T01380 CREB; mink, Mustela vison.
IN T00818 TFIIB; human, Homo sapiens.
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BS R04045.
BS R67609.
BS R67611.
BS R62805.
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DR TRANSPATH: MO000025637.
DR EMBL: D23677;
DR EMBL: Z35717;
DR UniProtKB: P69714;
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RN [1]; RE0002717.
RX PUBMED: 1827531.
RA Maguire H. F., Hoeffler J. P., Siddiqui A.
RT HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
RL Science 252:842-844 (1991).
RN [2]; RE0017799.
RX PUBMED: 11574165.
RA Ahn J. Y., Chung E. Y., Kwun H. J., Jang K. L.
RT Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway.
RL Gene 275:163-168 (2001).
RN [3]; RE0017803.
RX PUBMED: 11997040.
RA Han H. J., Jung E. Y., Lee W. J., Jang K. L.
RT Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein.
RL FEBS Lett. 518:169-172 (2002).
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