AC T04142
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ID T04142
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DT 29.12.2000 (created); rio.
DT 22.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA CHX10
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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HO ceh-10 T02980 (C. elegans).
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CL C0006; homeo.
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SZ 377 AA; 40.6 kDa (cDNA) (calc.).
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SQ MTGKAGAALAPSLPGKPKPDGAAAAAPPPPPPAAGAKPSSGPTPPRCTGFGIQEILGLNK
SQ EPPSHPRAALDSLPAGHLLAARSVLSPAGVGGVGMGLLGAGGIPGFYAQPTFLEVLSDPQ
SQ SVHLQPLARAPGQLDSSQTASSDSEDVSSSDRKMSKSSLNQSKKRKKRRHRTIFTSYQLE
SQ ELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGL
SQ YGAMVRHSIPLPESILKSAKDGIMESCAPWLLGMHKKSLEAAAEAGRKTEVERQALPKLD
SQ KGDKEERGSDPKTAISQEELRENSIAALRAKAQEHSTKVLGTIAGDTPRKPEKGEEVAED
SQ ERQTEKSSASQKEEKLI
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SC translated from EMBL #AF178671
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FT 50 57 
conserved octapeptide [3].
FT 105 348 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 165 225 
PS50071; HOMEOBOX_2.
FT 167 223 
PS50552; PAX.
FT 167 229 
SM00389; HOX_1.
FT 168 224 
PF00046; Homeobox domain.
FT 228 280 
CVC domain [2].
FT 318 338 
PF03826; OAR domain.
FT 321 335 
OAR domain [1].
FT 323 336 
PS50803; OAR.
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SF contains CVC domain which is a conserved region in CHX10/Vsx-1 T04139 T02970 T04143 T04144 and ceh-10 T02980 [2] [3];
SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [1];
SF two orthologs in chicken: CHX10 and CHX10-1 T04141 [2];
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CP (stage 12:) neural retina of invaginating optic vesicles, (stage 12-15:) ventral spinal cord, (stage 14-18:) neural retina, (stage 21-23:) retinal neuroepithelium, (stage 29:) vitreal region, (stage 35-adult:) bipolar cells of inner nuclear layer [2].
CN (stage 12:) pigment epithelium, lens, (stage 35-adult:) inner half of nuclear layer, ganglion cells [2].
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MX M00437 V$CHX10_01.
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DR TRANSPATH: MO000028044.
DR EMBL: AF178671;
DR UniProtKB: Q9IAL1;
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RN [1]; RE0014693.
RX PUBMED: 9096350.
RA Furukawa T., Kozak C. A., Cepko C. L.
RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997).
RN [2]; RE0015514.
RX PUBMED: 10640715.
RA Amy Chen C. M., Cepko C. L.
RT Expression of Chx10 and Chx10-1 in the developing chicken retina
RL Mech. Dev. 90:293-297 (2000).
RN [3]; RE0015515.
RX PUBMED: 7789259.
RA Svendsen P. C., McGhee J. D.
RT The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye
RL Development 121:1253-1262 (1995).
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