AC T00512
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ID T00512
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DT 21.10.1992 (created); ewi.
DT 11.12.2006 (updated); kau.
CO Copyright (C), QIAGEN.
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FA MRF4
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SY MRF4; Myf-6.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001055 Myf6.
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CL C0010; bHLH; 1.2.2.1.4.
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SF efficient DNA-binding only after heterodimerization with (e.g.) E12 [8];
SF strong cooperation between N- and C-terminal domains for MRF4-specific transcriptional activation [3];
SF phosphorylation at several Ser and Thr by PKA and PKC in vitro and in vivo;
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CP myogenic cells.
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FF myogenic factor, transcriptional activator [1];
FF activates MyoD and myogenin genes;
FF expression repressed by MyoD or myogenin [1];
FF it is transiently expressed after myogenin, before MyoD, and reappears during late stage of skeletal muscle development [6];
FF during limb bud development, it is expressed just at these late stages;
FF it is suggested to play a role in maintaining the differentiated stage [6];
FF down-regulated by bFGF [9];
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IN T00204 E12; human, Homo sapiens.
IN T00675 E12; rat, Rattus norvegicus.
IN T01787 E12; clawed frog, Xenopus laevis.
IN T00207 E47; human, Homo sapiens.
IN T01790 HTF4alpha; rat, Rattus norvegicus.
IN T01791 HTF4beta; rat, Rattus norvegicus.
IN T01789 HTF4gamma; rat, Rattus norvegicus.
IN T00512 MRF4; rat, Rattus norvegicus.
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MX M00804 V$E2A_Q2.
MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M03831 V$MRF4_Q3.
MX M00929 V$MYOD_Q6_01.
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DR TRANSPATH: MO000024980.
DR UniProtKB: P19335;
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RN [1]; RE0000703.
RX PUBMED: 2560751.
RA Rhodes S. J., Konieczny S. F.
RT Identification of MRF4: a new member of the muscle regulatory factor gene family
RL Genes Dev. 3:2050-2061 (1989).
RN [2]; RE0000968.
RX PUBMED: 1847137.
RA Chakraborty T., Brennan T., Olson E.
RT Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding
RL J. Biol. Chem. 266:2878-2882 (1991).
RN [3]; RE0001506.
RX PUBMED: 1658626.
RA Chakraborty T., Olson E. N.
RT Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4
RL Mol. Cell. Biol. 11:6103-6108 (1991).
RN [4]; RE0001507.
RX PUBMED: 1695319.
RA Yutzey K. E., Rhodes S. J., Konieczny S. F.
RT Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4
RL Mol. Cell. Biol. 10:3934-3944 (1990).
RN [5]; RE0002987.
RX PUBMED: 1328851.
RA Mak K.-L., To R. Q., Kong Y., Konieczny S. F.
RT The MRF4 activation domain is required to induce muscle-specific gene expression
RL Mol. Cell. Biol. 12:4334-4346 (1992).
RN [6]; RE0003271.
RX PUBMED: 1715299.
RA Hinterberger T. J., Sassoon D. A., Rhodes S. J., Konieczny S. F.
RT Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development
RL Dev. Biol. 147:144-156 (1991).
RN [7]; RE0003274.
RX PUBMED: 1639267.
RA Hinterberger T. J., Mays J. L., Konieczny S. F.
RT Structure and myofiber-specific expression of the rat muscle regulatory gene MRF4
RL Gene 117:201-207 (1992).
RN [8]; RE0003406.
RX PUBMED: 1311321.
RA Lin H., Konieczny S. F.
RT Identification of MRF4, myogenin, and E12 oligomer complexes by cheical cross-linking and two-dimensional gel electrophoresis
RL J. Biol. Chem. 267:4773-4780 (1992).
RN [9]; RE0003407.
RX PUBMED: 8413199.
RA Hardy S., Kong Y., Konieczny S. F.
RT Fibroblast growth factor inhibits MRF4 activity independently of the phosporylation status of a conserved threonine residue within the DNA-binding domain
RL Mol. Cell. Biol. 13:5943-5956 (1993).
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