AC T01790
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ID T01790
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DT 03.05.1996 (created); ewi.
DT 26.10.2006 (updated); ili.
CO Copyright (C), QIAGEN.
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FA HTF4alpha
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SY ALF1B; REBbeta; salivary-specific CRE-binding protein alpha; SCBPA; TCF12; transcription factor 12.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014506 Tcf12.
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CL C0010; bHLH.
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SZ 707 AA; 75.9 kDa (cDNA) (calc.).
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SQ MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSW
SQ GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLY
SQ SRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQA
SQ KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSS
SQ SNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG
SQ STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP
SQ STPVGSPSPLTAGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVC
SQ EQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNAPIGNLNSNYGGSS
SQ LVTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPESFRGGVQNQSGSVVP
SQ TEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIERE
SQ KERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVR
SQ ERNLNPKAACLKRREEEKVSAASAEPPTTLPGTHPGLSETTNPMGHL
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SC conceptually translated from EMBL/GenBank/DDBJ #L09656 and #S53920
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FT 72 639 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 405 435 
helical inhibitory domain (HID) [1].
FT 601 656 
PS50888; HLH.
FT 603 656 
PF00010; Helix-loop-helix DNA-binding domain.
FT 608 661 
SM00353; finulus.
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SF two splice variants are SCBPgamma and SCBPbeta [2];
SF the insert of the alpha variant has been reported to be similar to ankyrin-repeats, probably to fold as an amphiphilic alpha-helix, and to exert inhibiting function on factor dimerization [1];
SF it thus binds to DNA in a much less effective way than SCBPgamma [1];
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CP ubiquitous [1].
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FF weaker activator than SCBPgamma, responding to enhanced cAMP levels [2];
FF HTF4alpha (REBbeta) is predominant over SCBPgamma (REBalpha) in the pituitary gland and brain [1];
FF gradual decrease from embryonic day 14 to neonatal day 10 [1];
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IN T01789 HTF4gamma; rat, Rattus norvegicus.
IN T00484 MASH-1; rat, Rattus norvegicus.
IN T00485 MASH-2; rat, Rattus norvegicus.
IN T00512 MRF4; rat, Rattus norvegicus.
IN T00526 MyoD; mouse, Mus musculus.
IN T08441 Sox-10; rat, Rattus norvegicus.
IN T14088 Sox-8; mouse, Mus musculus.
IN T09097 SRY; human, Homo sapiens.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M00698 V$HEB_Q6.
MX M02018 V$HTF4_Q2.
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DR TRANSPATH: MO000025927.
DR EMBL: L09656;
DR EMBL: S53920;
DR UniProtKB: P51514-1; HTF4_RAT.
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RN [1]; RE0003628.
RX PUBMED: 8422988.
RA Klein E. S., Simmons D. M., Swanson L. W., Rosenfeld M. G.
RT Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein
RL Genes Dev. 7:55-71 (1993).
RN [2]; RE0003729.
RX PUBMED: 7683670.
RA Lin H. H., Li W. Y., Ann D. K.
RT The helix-loop-helix proteins (salivary-specific cAMP response element-binding proteins) can modulate cAMP-inducible RP4 gene expression in salivary cells
RL J. Biol. Chem. 268:10214-10220 (1993).
RN [3]; RE0003746.
RX PUBMED: 1335317.
RA Lin H. H., Ann D. K.
RT Identification of cis- and trans-acting factors regulating the expression of rat salivary-specific RP4 gene
RL Gene Expr. 2:365-377 (1992).
RN [4]; RE0048308.
RX PUBMED: 16582099.
RA Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
RT The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
RL Nucleic Acids Res. 34:1735-1744 (2006).
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