AC T01789
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ID T01789
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DT 03.05.1996 (created); ewi.
DT 13.10.2009 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA HTF4gamma
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SY ALF1A; ALF1A (mouse); HEB; REBalpha; salivary-specific CRE-binding protein gamma; SCBP; TCF12; transcription factor 12.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014506 Tcf12.
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CL C0010; bHLH.
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SZ 682 AA; 72.9 kDa (cDNA) (calc.).
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SQ MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSW
SQ GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLY
SQ SRDCGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSSSATSSRRRPLHDSVALDPLQA
SQ KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSS
SQ SNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG
SQ STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP
SQ STPVGSPSPLTAGTSQWPRAGGQAPSSPSYENSLHSLSRMEDRLDRLDDAIHVLRNHAVG
SQ PSTSLPTSHSDIHSLLGPSHNAPIGNLNSNYGGSSLVTNSRSASMVGTHREDSVSLNGNH
SQ SVLSSTVAASNTELNHKTPESFRGGVQNQSGSVVPNEIKTENKEKDENLHEPPSSDDMKS
SQ DDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKEL
SQ GRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAASAE
SQ PPTTLPGTHPGLSETTNPMGHL
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SC conceptually translated from EMBL/GenBank/DDBJ #L09656 and #S53920 and edited
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FT 117 614 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 576 631 
PS50888; HLH.
FT 578 631 
PF00010; Helix-loop-helix DNA-binding domain.
FT 583 636 
SM00353; finulus.
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SF two splice variants are SCBPalpha and -beta revealing 25-AA- or 24-AA-inserts between positions 397 and 398 [2];
SF the inserts have been reported to be similar to ankyrin-repeats and exert inhibiting function on factor dimerization [1];
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CP ubiquitous [1].
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FF activator, responding to enhanced cAMP levels [2];
FF HTF4gamma (REBalpha) is predominant over SCBPalpha (REBbeta) in lung, kidney and spleen [1];
FF sharp decline between embryonic day 14 and 15 [1];
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IN T01790 HTF4alpha; rat, Rattus norvegicus.
IN T01791 HTF4beta; rat, Rattus norvegicus.
IN T01789 HTF4gamma; rat, Rattus norvegicus.
IN T00484 MASH-1; rat, Rattus norvegicus.
IN T00485 MASH-2; rat, Rattus norvegicus.
IN T00512 MRF4; rat, Rattus norvegicus.
IN T00526 MyoD; mouse, Mus musculus.
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MX M00973 V$E2A_Q6.
MX M01034 V$EBOX_Q6_01.
MX M00698 V$HEB_Q6.
MX M02018 V$HTF4_Q2.
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DR TRANSPATH: MO000025926.
DR EMBL: L09656;
DR EMBL: S53920;
DR UniProtKB: P51514-3; HTF4_RAT.
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RN [1]; RE0003628.
RX PUBMED: 8422988.
RA Klein E. S., Simmons D. M., Swanson L. W., Rosenfeld M. G.
RT Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein
RL Genes Dev. 7:55-71 (1993).
RN [2]; RE0003729.
RX PUBMED: 7683670.
RA Lin H. H., Li W. Y., Ann D. K.
RT The helix-loop-helix proteins (salivary-specific cAMP response element-binding proteins) can modulate cAMP-inducible RP4 gene expression in salivary cells
RL J. Biol. Chem. 268:10214-10220 (1993).
RN [3]; RE0003746.
RX PUBMED: 1335317.
RA Lin H. H., Ann D. K.
RT Identification of cis- and trans-acting factors regulating the expression of rat salivary-specific RP4 gene
RL Gene Expr. 2:365-377 (1992).
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