AC T06013
XX
ID T06013
XX
DT 11.06.2004 (created); cch.
DT 30.07.2014 (updated); sla.
CO Copyright (C), QIAGEN.
XX
FA DeltaN p73gamma
XX
SY DN p73 gamma; dominant negative p73gamma; tumor protein p73 isoform d.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G005523 TP73; HGNC: tp73.
XX
CL C0057; P53; 6.3.1.0.3.9.
XX
SZ 427 AA; 47.7 kDa (calc.).
XX
SQ MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTM
SQ SPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPP
SQ PPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDP
SQ VTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRS
SQ FEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRH
SQ GDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPR
SQ SASQQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPRQFFNRIGVSKLHRVFHLPRVTEHL
SQ PPAEPDH
XX
SC Swiss-Prot#O15350-10
XX
FT 53 342 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 64 260 
PF00870; P53 DNA-binding domain.
FT 296 337 
PF07710; P53 tetramerisation motif.
XX
SF several alternative products are known, p73alpha T04931, p73beta T06137, p73gamma T06142, p73delta T06143, p73epsilon T06144, p73zeta T06145, p73kappa T06139, p73eta T06179, DeltaN p73alpha T06002, DeltaN p73beta T06003, DeltaNp73gamma T06013;
SF this isoform lack N-terminal transactivation domain [1];
XX
FF is able to activate transcription (weakly) [2];
FF suppressor of p53 and TAp73 variants, blocks their transactivation potential [1];
FF blocks induction of apoptosis [1];
XX
MX M00761 V$P53DECAMER_Q2.
MX M03558 V$P73_Q6.
XX
DR TRANSPATH: MO000043790.
DR EMBL: AY040829;
DR UniProtKB: O15350-10;
XX
RN [1]; RE0024719.
RX PUBMED: 11753569.
RA Grob T. J., Novak U., Maisse C., Barcaroli D., Luthi A. U., Pirnia F., Hugli B., Graber H. U., De Laurenzi V., Fey M. F., Melino G., Tobler A.
RT Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.
RL Cell Death Differ. 8:1213-1223 (2001).
RN [2]; RE0024755.
RX PUBMED: 14701724.
RA Liu G., Nozell S., Xiao H., Chen X.
RT DeltaNp73beta is active in transactivation and growth suppression.
RL Mol. Cell. Biol. 24:487-501 (2004).
XX
//