TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06142 XX ID T06142 XX DT 13.09.2004 (created); oke. DT 30.07.2014 (updated); sla. CO Copyright (C), QIAGEN. XX FA p73gamma XX SY p73 gamma; TAp73gamma; tumor protein p73 isoform i; tumor suppressor p73, isoform gamma. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005523 TP73; HGNC: tp73. XX CL C0057; P53; XX SZ 476 AA; 53.0 kDa (calc.). XX SQ MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTS SQ VMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTD SQ YPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPV SQ YKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPY SQ EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGR SQ DRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVR SQ GRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQQRRDEQQ SQ PQRPVHGLGVPLHSATPLPRRPQPRQFFNRIGVSKLHRVFHLPRVTEHLPPAEPDH XX SC Swiss-Prot#O15350-3 XX FT 102 391 PF00478; IMP dehydrogenase / GMP reductase domain. FT 113 309 PF00870; P53 DNA-binding domain. FT 345 386 PF07710; P53 tetramerisation motif. FT 400 475 unique sequence resulted from a frame shift in comparison with p73alpha [1]. XX SF several alternative products are known, p73alpha T04931, p73beta T06137, p73gamma T06142, p73delta T06143, p73epsilon T06144, p73zeta T06145, p73kappa T06139, p73eta T06179, DeltaN p73alpha T06002, DeltaN p73beta T06003, DeltaNp73gamma T06013; SF this isoform lack exon 11 in comparison with p73alpha, alternative splicing results in a frame shift leading to the translation of unique 76 AA [1]; SF unique C-terminus in comparison with other isoforms [1]; SF has transactivation, CBP/p300 binding, DNA binding, and oligomerization domains (by similarity with p53) [1]; SF strong interactions with p73alpha, p73beta (strongest), p73gamma and p73delta [1]; XX FF activator, is able to activate transcription from the p21waf1 promoter although significantly less efficiently than p53 or p73beta [1] [2] [3] [4]; FF suppresses transcriptional activity of p53 [4]; XX MX M00761 V$P53DECAMER_Q2. MX M03558 V$P73_Q6. XX DR TRANSPATH: MO000042381. DR UniProtKB: O15350-3; XX RN [1]; RE0017269. RX PUBMED: 9802988. RA De Laurenzi V., Costanzo A., Barcaroli D., Terrinoni A., Falco M., Annicchiarico-Petruzzelli M., Levrero M., Melino G. RT Two new p73 splice variants, gamma and delta, with different transcriptional activity RL J. Exp. Med. 188:1763-1768 (1998). RN [2]; RE0024735. RX PUBMED: 10809758. RA De Laurenzi V., Raschella G., Barcaroli D., Annicchiarico-Petruzzelli M., Ranalli M., Catani M. V., Tanno B., Costanzo A., Levrero M., Melino G. RT Induction of neuronal differentiation by p73 in a neuroblastoma cell line. RL J. Biol. Chem. 275:15226-15231 (2000). RN [3]; RE0024768. RX PUBMED: 11389695. RA Ueda Y., Hijikata M., Takagi S., Chiba T., Shimotohno K. RT Transcriptional activities of p73 splicing variants are regulated by inter-variant association. RL Biochem. J. 356:859-866 (2001). RN [4]; RE0024769. RX PUBMED: 10490834. RA Ueda Y., Hijikata M., Takagi S., Chiba T., Shimotohno K. RT New p73 variants with altered C-terminal structures have varied transcriptional activities. RL Oncogene 18:4993-4998 (1999). RN [5]; RE0049678. RX PUBMED: 15572666. RA Munarriz E., Barcaroli D., Stephanou A., Townsend P. A., Maisse C., Terrinoni A., Neale M. H., Martin S. J., Latchman D. S., Knight R. A., Melino G., De Laurenzi V. RT PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. RL Mol. Cell. Biol. 24:10593-10610 (2004). RN [6]; RE0049870. RX PUBMED: 12730672. RA Alisi A., Giambartolomei S., Cupelli F., Merlo P., Fontemaggi G., Spaziani A., Balsano C. RT Physical and functional interaction between HCV core protein and the different p73 isoforms. RL Oncogene 22:2573-2580 (2003). RN [7]; RE0063151. RX PUBMED: 17304243. RA Crighton D., O'Prey J., Bell H. S., Ryan K. M. RT p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. RL Cell Death Differ. 14:1071-1079 (2007). XX //