AC T06143
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ID T06143
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DT 13.09.2004 (created); oke.
DT 30.07.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA p73delta
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SY tumor protein p73 isoform j; tumor suppressor p73, isoform delta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005523 TP73; HGNC: tp73.
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CL C0057; P53; 6.3.1.0.3.4.
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SZ 403 AA; 44.5 kDa (calc.).
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SQ MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTS
SQ VMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTD
SQ YPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPV
SQ YKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPY
SQ EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGR
SQ DRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVR
SQ GRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPTWGP
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SC Swiss-Prot#O15350-4
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FT 102 391 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 113 309 
PF00870; P53 DNA-binding domain.
FT 345 386 
PF07710; P53 tetramerisation motif.
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SF several alternative products are known, p73alpha T04931, p73beta T06137, p73gamma T06142, p73delta T06143, p73epsilon T06144, p73zeta T06145, p73kappa T06139, p73eta T06179, DeltaN p73alpha T06002, DeltaN p73beta T06003, DeltaNp73gamma T06013;
SF this isoform lack exons 11, 12 and 13 in comparison with p73alpha [1];
SF has transactivation, CBP/p300 binding, DNA binding, and oligomerization domains (by similarity with p53) [1];
SF strong interactions with p73alpha, p73gamma and p73delta, interactions with p73beta are weak [1];
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FF activator, is able to activate transcription from the p21waf1 promoter, effect is intermediate and similar to that of p73alpha and p73beta [1] [2];
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MX M00761 V$P53DECAMER_Q2.
MX M03558 V$P73_Q6.
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DR TRANSPATH: MO000043749.
DR UniProtKB: O15350-4;
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RN [1]; RE0017269.
RX PUBMED: 9802988.
RA De Laurenzi V., Costanzo A., Barcaroli D., Terrinoni A., Falco M., Annicchiarico-Petruzzelli M., Levrero M., Melino G.
RT Two new p73 splice variants, gamma and delta, with different transcriptional activity
RL J. Exp. Med. 188:1763-1768 (1998).
RN [2]; RE0024735.
RX PUBMED: 10809758.
RA De Laurenzi V., Raschella G., Barcaroli D., Annicchiarico-Petruzzelli M., Ranalli M., Catani M. V., Tanno B., Costanzo A., Levrero M., Melino G.
RT Induction of neuronal differentiation by p73 in a neuroblastoma cell line.
RL J. Biol. Chem. 275:15226-15231 (2000).
RN [3]; RE0049870.
RX PUBMED: 12730672.
RA Alisi A., Giambartolomei S., Cupelli F., Merlo P., Fontemaggi G., Spaziani A., Balsano C.
RT Physical and functional interaction between HCV core protein and the different p73 isoforms.
RL Oncogene 22:2573-2580 (2003).
RN [4]; RE0050157.
RX PUBMED: 17535448.
RA Paliwal P., Radha V., Swarup G.
RT Regulation of p73 by Hck through kinase-dependent and independent mechanisms.
RL BMC Mol. Biol. 8:45 (2007).
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